Fetal fibronectin in vaginal fluid of women in prolonged pregnancy.

Gynecol Obstet Invest

Department of Obstetrics and Gynecology, Sahlgrens University Hospital, University of Göteborg, Sweden.

Published: January 1998

The aim of this study was to determine fetal fibronectin in vaginal fluid of women in prolonged pregnancy, its relationship to a modified Bishop score and its predictiveness of delivery within 3 days. Vaginal samples were collected from 80 women at 42 weeks of gestation for the fetal fibronectin assay. A modified Bishop score was estimated. Fetal fibronectin was determined by a quantitative enzyme immunoassay. The concentration of fetal fibronectin in vaginal fluid was elevated in only 36 of the 80 women. The Bishop score and the time between sampling and delivery were not associated with an elevated fetal fibronectin (> or = 0.05 mg/l). We conclude that fetal fibronectin is not a good indicator of delivery within 3 days. The findings add to our understanding of the complexity of the etiology of postterm labor.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000291533DOI Listing

Publication Analysis

Top Keywords

fetal fibronectin
28
fibronectin vaginal
12
vaginal fluid
12
bishop score
12
fluid women
8
women prolonged
8
prolonged pregnancy
8
modified bishop
8
delivery days
8
fetal
7

Similar Publications

Preeclampsia (PE) is a gestational complication affecting 5% to 10% of all pregnancies. PE is characterized by hypertension and endothelial dysfunction, whose etiology involves, among other factors, alterations in the extracellular matrix (ECM) that can compromise vascular remodeling and trophoblast invasion, ie, processes essential for placental development. Endothelial dysfunction is caused by release of antiangiogenic factors, mainly a soluble fms-like tyrosine kinase-1 (sFlt-1), which antagonizes two endothelial angiogenic factors, the vascular endothelial growth factor (VEGF) and placental growth factor (PLGF).

View Article and Find Full Text PDF
Article Synopsis
  • Preeclampsia is a condition with serious risks for mothers and babies, and new angiogenic markers are being used to help diagnose it quickly in clinical settings.
  • The study analyzed the effectiveness of various point-of-care tests for predicting preeclampsia, focusing on their sensitivity and specificity based on data from 17 relevant studies.
  • Glycosylated fibronectin testing showed promising results with a sensitivity of 0.80 and specificity of 0.84, indicating it could be a valuable tool for clinical decisions regarding preeclampsia in high-risk patients.
View Article and Find Full Text PDF

Objectives: To evaluate glycosylated fibronectin (GlyFn) as a novel biomarker for preeclampsia and preeclampsia-related complications, and to compare GlyFn to traditional biomarkers, including soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF).

Study Design: Secondary analysis of a prospective cohort study (n = 524) with suspected preeclampsia (control), gestational hypertension (GH), or confirmed preeclampsia/hemolysis, elevated liver enzymes and low platelets syndrome (PE/HELLP).

Main Outcome Measures: GlyFn levels in PE/HELLP versus control and GH.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!