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MicroRNA Nobel Prize: Timely Recognition and High Anticipation of Future Products-A Prospective Analysis.
Int J Mol Sci
November 2024
DEI Biopharma, Kampala P.O. Box 35854, Uganda.
MicroRNAs (miRNAs) maintain cellular homeostasis by blocking mRNAs by binding with them to fine-tune the expression of genes across numerous biological pathways. The 2024 Nobel Prize in Medicine and Physiology for discovering miRNAs was long overdue. We anticipate a deluge of research work involving miRNAs to repeat the history of prizes awarded for research on other RNAs.
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- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Identification of FDA-approved drugs that induce heart regeneration in mammals.
Nat Cardiovasc Res
March 2024
Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Targeting Meis1 and Hoxb13 transcriptional activity could be a viable therapeutic strategy for heart regeneration. In this study, we performd an in silico screening to identify FDA-approved drugs that can inhibit Meis1 and Hoxb13 transcriptional activity based on the resolved crystal structure of Meis1 and Hoxb13 bound to DNA. Paromomycin (Paro) and neomycin (Neo) induced proliferation of neonatal rat ventricular myocytes in vitro and displayed dose-dependent inhibition of Meis1 and Hoxb13 transcriptional activity by luciferase assay and disruption of DNA binding by electromobility shift assay.
View Article and Find Full Text PDFCongress Must Update FDA Regulations for Medical AI.
JAMA Health Forum
July 2024
American Enterprise Institute, Washington, DC.
Drug review process advancement and required manufacturer and contract research oraganization responses.
J Toxicol Pathol
April 2024
Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-0064, Japan.
The United States Senate passed the "FDA Modernization Act 2.0." on September 29, 2022.
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