Expression of cytokeratins nos. 7 and 19 has been examined during pre- and postnatal ontogenesis in rat liver. Cells expressing cytokeratin no. 19 appeared around large incoming vessels in the liver at days 17-18 of gestation. From day 20 of gestation and during the first week of postnatal ontogenesis, cholangiocytes and periportal hepatocytes could be stained with antibodies against cytokeratin no. 19. The expression of cytokeratin no. 7 begins later than cytokeratin no. 19, and it is present only in cholangiocytes, throughout pre- and postnatal ontogenesis. Since pre- and postnatal hepatocytes are capable of expressing cytokeratin no. 19, we discuss possible use of this marker to study cytodifferentiation of epithelial cell lines in rat liver.
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