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PAR-dCLIP: Enabling detection of RNA binding protein target transcripts bound at 5' termini through the incorporation of a decapping step.
Methods Enzymol
October 2024
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:
RNA binding proteins (RBPs) are responsible for facilitating a wealth of post-transcriptional gene regulatory functions. The role of an RBP on regulated transcripts can be investigated through a pull-down of the RBP and high-throughput sequencing (HTS) of the associated transcripts. Photoactivatable Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP), is one such pull-down method that isolates, detects, and sequences the cDNA of RBP-associated transcripts.
View Article and Find Full Text PDFEffects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats.
Drug Alcohol Depend Rep
September 2024
Department of Psychology, University of Kentucky, Lexington, KY 40536, USA.
Background: Alcohol use in adolescence may increase susceptibility to substance use disorders (SUDs) in adulthood. This study determined if voluntary ethanol (EtOH) consumption during adolescence, combined with social isolation, alters the trajectory of EtOH and nicotine intake during adulthood, as well as activating brain neuroinflammation.
Methods: Adolescent male isolate- and group-housed rats were given 0.
Wavelet transform of autoradiographs: Analysis of MOX fuel heterogeneity.
Appl Radiat Isot
September 2024
Electronics & Instrumentation Group, BARC, Mumbai, India.
Radiation imaging is extensively applied in nuclear industry for various purposes including fuel characterization. Accurate quantitative evaluation of these radiographic images is difficult by the existing manual process and therefore image analytical methods have been attempted. The method of wavelet transform analysis has been applied on Gamma autoradiography (GAR) images of experimental (U, Pu)O mixed oxide (MOX) fuel pins with the objective to investigate the effectiveness of the method for fuel homogeneity characterization.
View Article and Find Full Text PDFNicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT receptor activation.
Front Psychiatry
June 2024
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine (UCI), Irvine, CA, United States.
Introduction: Abuse or misuse of tobacco, e-cigarettes, or antidepressants may have serious clinical consequences during adolescence, a sensitive period during brain development when the distinct neurobiology of adolescent serotonin (5-HT) and dopamine (DA) systems create unique behavioral vulnerabilities to drugs of abuse.
Methods: Using a pharmacological approach, we modeled the behavioral and neurochemical effects of subchronic (4-day) nicotine (60µg/kg, i.v.
Using spectroscopic autoradiography of alpha particles for the quantitative mapping of Ra ultra-traces in geo-materials.
J Environ Radioact
March 2024
IC2MP - HydrASA, Poitiers University UMR, 7285, CNRS, France. Electronic address:
The measurement of Ra and the identification of Ra-bearing minerals are important for studying the behavior of radium in the environment. Various instruments for measuring Ra are currently used: among the radiometric techniques that measure in bulk (no spatialization), there are gamma spectrometers and alpha spectrometers. Other instruments such as SEM-EDS can map the chemical elements thus providing information on the distribution of Ra, but are limited for ultra-trace analyses on natural geomaterials.
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