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Heterogeneous and multiple conformational transition pathways between pseudoknots of the SARS-CoV-2 frameshift element.
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry, New York University, New York, NY 10003.
Frameshifting is an essential mechanism employed by many viruses including coronaviruses to produce viral proteins from a compact RNA genome. It is facilitated by specific RNA folds in the frameshift element (FSE), which has emerged as an important therapeutic target. For SARS-CoV-2, a specific 3-stem pseudoknot has been identified to stimulate frameshifting.
View Article and Find Full Text PDFDesign and Aerodynamic Analysis of a Flapping Mechanism for Foldable Biomimetic Aircraft.
Biomimetics (Basel)
January 2025
Automotive Parts Research Institute, Hunan University of Technology, Hengyang 421002, China.
This study investigates the unsteady aerodynamic mechanisms underlying the efficient flight of birds and proposes a biomimetic flapping-wing aircraft design utilizing a double-crank double-rocker mechanism. Building upon a detailed analysis of avian flight dynamics, a two-stage foldable flapping mechanism was developed, integrating an optimized double-crank double-rocker structure with a secondary linkage system. This design enables synchronized wing flapping and spanwise folding, significantly enhancing aerodynamic efficiency and dynamic performance.
View Article and Find Full Text PDFMaximum-Power Stirling-like Heat Engine with a Harmonically Confined Brownian Particle.
Entropy (Basel)
January 2025
Física Teórica, Universidad de Sevilla, Apartado de Correos 1065, E-41080 Sevilla, Spain.
Heat engines transform thermal energy into useful work, operating in a cyclic manner. For centuries, they have played a key role in industrial and technological development. Historically, only gases and liquids have been used as working substances, but the technical advances achieved in recent decades allow for expanding the experimental possibilities and designing engines operating with a single particle.
View Article and Find Full Text PDFMinimally invasive management of hidradenitis suppurativa using a 1470 nm diode laser: a step-by-step description of our technique.
BMC Surg
January 2025
Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Background: The management of hidradenitis suppurativa (HS) requires a multidisciplinary approach to ensure sustainable treatment results, especially in the advanced stages. Traditionally, deroofing and wide excision represented commonly employed surgical techniques. Due to the recurrent nature of HS, tissue preservation should be a relevant aspect of surgical management.
View Article and Find Full Text PDFIntegrating machine learning with advanced processing and characterization for polycrystalline materials: a methodology review and application to iron-based superconductors.
Sci Technol Adv Mater
December 2024
JST-CREST, Saitama, Japan.
In this review, we present a new set of machine learning-based materials research methodologies for polycrystalline materials developed through the Core Research for Evolutionary Science and Technology project of the Japan Science and Technology Agency. We focus on the constituents of polycrystalline materials (i.e.
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