AI Article Synopsis
- Helicobacter pylori is a highly diverse bacteria, and studying its strains from individual patients can reveal insights into how it causes disease and evolves.
- Researchers at the Japanese-Peruvian Polyclinic analyzed H. pylori isolates to determine their susceptibility to metronidazole and to investigate their genotypes using RAPD fingerprinting across 24 patients.
- The findings showed a mix of metronidazole-susceptible and resistant strains in many patients, but a similarity in their RAPD types suggests that certain genotypes are favored during prolonged infections, possibly influenced by the common use of metronidazole in Peru.
Article Abstract
Helicobacter pylori is an extremely diverse species. The characterization of strains isolated from individual patients should give insights into colonization and disease mechanisms and bacterial evolution. We studied H. pylori isolates from patients in the Japanese-Peruvian Polyclinic in Lima, Peru, by determining metronidazole susceptibility or resistance and by random amplified polymorphic DNA (RAPD) fingerprinting (a measure of overall genotype). Strains isolated from several biopsy specimens from each of 24 patients were studied. Both metronidazole-susceptible and -resistant strains were isolated from 13 patients, whereas strains of more than one RAPD type were isolated from only seven patients. We propose that the homogeneity in RAPD fingerprints for strains isolated from most persons reflects selection for particular H. pylori genotypes during chronic infection in individual hosts and the human diversity in traits that are important to this pathogen. Carriage of related metronidazole-resistant and -susceptible strains could reflect frequent metronidazole use in Peru and alternating selection for resistant and susceptible phenotypes during and after metronidazole therapy.
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| http://dx.doi.org/10.1086/516081 | DOI Listing |
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