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Linezolid-Induced Lactic Acidosis: A Case Report.
Cureus
December 2024
Nephrology, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, USA.
Linezolid, an oxazolidinone antibiotic, is widely used to treat infections caused by gram-positive bacteria that are resistant to other antibiotics. It inhibits bacterial protein synthesis by targeting rRNA. Although generally safe when used for short durations in uncomplicated patients, prolonged use may lead to adverse effects.
View Article and Find Full Text PDFMitochondrial DNA 3243 mutation may be associated with positivity of zinc transporter 8 autoantibody in cases of slowly progressive type 1 diabetes mellitus.
Diabetol Int
January 2025
Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyamamachi, Iruma-Gun, Saitama, 350-0495 Japan.
Slowly progressive type 1 diabetes mellitus (SPIDDM), solely positive for zinc transporter 8 autoantibody (ZnT8A) is rare, and the factors involved in the single positivity remain largely unknown. Thus, this case report aimed to infer the factors based on a literature review. A 40-year-old female was hospitalized for hyperglycemia.
View Article and Find Full Text PDFNavigating the dichotomy of reactive oxygen, nitrogen, and sulfur species: detection strategies and therapeutic interventions.
RSC Chem Biol
January 2025
Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research Jakkur P.O. Bengaluru Karnataka 560064 India
Reactive oxygen, nitrogen and sulfur species (RONSS) collectively encompasses a variety of energetically dynamic entities that emerge as inherent characteristics of aerobic life. This broad category includes reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS). A conundrum arises from the indispensable role of RONSS in redox signalling, while its overproduction in the mitochondria poses deleterious effects.
View Article and Find Full Text PDFMultiple Coenurus cerebralis Cysts Detected in a Sheep Brain and Molecular Characterization of the Individual Cysts.
Vet Ital
January 2025
Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, Elazig, Türkiye.
Taenia multiceps is found in canids and in its larval stage is known as Coenurus cerebralis causes coenurosis. The disease has a significant impact on the economic value of sheep and goats. The aim of the current study was to identify multiple cysts in the brain of a sheep displaying common symptoms of C.
View Article and Find Full Text PDFIntestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress.
J Intensive Med
January 2025
Department of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background: Cholestasis plays a critical role in sepsis-associated liver injury (SALI). Intestine-derived fibroblast growth factor 19 (FGF19) is a key regulator for bile acid homeostasis. However, the roles and underlying mechanisms of FGF19 in SALI are still unclear.
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