Prototheca wickerhamii is a rare cause of systemic infection in humans. While some cases occur in previously healthy individuals, others are associated with a variety of preexisting diseases. Here we present, for the first time, a case of P. wickerhamii algaemia in a patient with myasthenia gravis. The patient was successfully treated with amphotericin B.
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http://dx.doi.org/10.1128/jcm.35.12.3305-3307.1997 | DOI Listing |
Microbiol Spectr
January 2025
Institute for Animal Hygiene and Environmental Health, Freie Universität Berlin, Berlin, Germany.
are ubiquitous algae and occasional pathogens of humans and animals. While rare, the infection is often fatal and treatment options are limited to antifungals with low efficiency. Here, using growth curve assays, we demonstrate that five pathogenic species of () were fully inhibited by 50-100 μg/mL of herbicide glyphosate, suggesting novel pathways that can be considered for anti-algal drug development.
View Article and Find Full Text PDFVet Res Commun
January 2025
Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
Protothecosis is a severe, emerging opportunistic infection caused by the saprophytic, achlorophyllous microalgae of the genus Prototheca. Though uncommon, human and animal cases are increasing worldwide, making awareness of this fungal-like pathogen important in both human and veterinary medicine. We report a fatal case of disseminated protothecosis caused by P.
View Article and Find Full Text PDFJ Vet Intern Med
December 2024
Department of Medical Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Background: Protothecosis in dogs is a rare, yet emerging disease, distinguished by its often-aggressive clinical course and high fatality rate. Our study was conducted to enhance treatment protocols for affected dogs by better understanding the genetic diversity and drug resistance patterns of Prototheca species.
Objectives: To identify species and drug susceptibility profiles of an international collection of 28 Prototheca strains isolated from cases of protothecosis in dogs.
PLoS Negl Trop Dis
November 2024
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil.
J Med Microbiol
October 2024
Dermatology Hospital of Fuzhou, Fuzhou 350025, PR China.
is an opportunistic pathogen that can infect both humans and animals, of which () being the most significant pathogenic green algae. The incidence of human diseases caused by has been on the rise, yet there is a significant gap in genetic research pertaining to the pathophysiological aspects of these infections. The aim of this study is to present the whole genome data from the clinical isolate InPu-22_FZ strain and to understand its genomic characteristics through comparative genomic analysis and phylogenetic tree analysis.
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