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Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl Stress Through Nrf2/GSH Activation in SH-SY5Y Cells.
Neurochem Res
November 2024
Department of Analytical Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan.
Article Synopsis
- Carbonyl stress is caused by the buildup of advanced glycation end products (AGEs) and is linked to diseases like diabetes and neurodegenerative disorders, including multiple sclerosis (MS).
- The study explores how dimethyl fumarate (DMF), which activates the Nrf2 pathway, can counteract carbonyl stress and protect neuronal cells from damage caused by Methylglyoxal (MGO).
- Findings show that DMF enhances glutathione levels and reduces harmful MG-H1-modified protein accumulation in cells, indicating that the Nrf2 pathway is crucial for the protective effects of DMF.
Benefits of self-paced concurrent training on lung function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis.
Neurodegener Dis Manag
October 2024
Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisia.
Studying the effects of self-paced concurrent high-intensity interval training and resistance training (HIIT-RT) on respiratory function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis (PwMS). Twenty-three PwMS were randomized into a 12-week training group (three times per week) (TG, n = 11) or a control group (CG, n = 12). Lung function (spirometry), aerobic capacity (graded cardiopulmonary-exercise-testing) and perceived fatigue (Fatigue Severity Scale (FSS)) were evaluated pre- and post-intervention.
View Article and Find Full Text PDFExploring humor as a coping factor against depressive mood and fear of progression in people with multiple sclerosis with moderate disability: A cross-sectional analysis of a rehabilitation cohort.
Mult Scler Relat Disord
November 2024
Department of Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpenerstr. 62, D-50937 Cologne, Germany. Electronic address:
Article Synopsis
- People with multiple sclerosis (pwMS) often feel stressed and might get depressed or scared about their condition. This research looks at how humor could help them cope better.
- The study involved 77 German people with MS, and it checked how their humor skills related to their mood and fear of getting worse.
- Results showed that those who had a good sense of humor felt less depressed and scared about their condition, so using humor might be a good way to help them feel better, but more research is needed.
Autoimmune Neurobeachin Cerebellar Ataxia.
Mov Disord
December 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Background: There are more than 30 immunoglobulin G (IgG) autoantibody biomarkers of autoimmune cerebellar ataxia reported.
Objective: To describe a novel IgG biomarker targeting neurobeachin, a scaffolding protein integral to synapse formation and function.
Methods: Clinical and laboratory-based assessment was used for a novel diagnostic biomarker of autoimmune ataxia.
Motor progression trajectories and risk of mild cognitive impairment in Parkinson's disease: A latent class trajectory model from PPMI cohort.
CNS Neurosci Ther
August 2024
Shantou University Medical College, Shantou, Guangdong Province, China.
Aims: Rare studies have investigated the association between heterogeneity of motor progression and risk of early cognitive impairment in Parkinson's disease (PD). In this study, we aim to identify distinct trajectories of motor progression longitudinally and investigate their impact on predicting mild cognitive impairment (MCI).
Methods: A 5-year cohort including 415 PD patients at baseline was collected from the Parkinson's Progression Markers Initiative.
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