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Exploring the immunological functions of thioredoxin domain-containing protein 17 (TXNDC17) in chub mackerel (Scomber japonicus): Immune response and cellular redox homeostasis.
Dev Comp Immunol
January 2025
Department of Marine Life Sciences & Center for Genomic Selection in Korean Aquaculture, Jeju National University, Jeju, 63243, Republic of Korea; Marine Life Research Institute, Jeju National University, Jeju, 63333, Republic of Korea. Electronic address:
All organisms have evolved sophisticated antioxidant networks and enzymes to counteract reactive radicals, among which thioredoxin (Trx) systems are especially noteworthy. Thioredoxin domain-containing protein 17 (TXNDC17) is a ubiquitously expressed enzyme with oxidoreductase activity belonging to the Trx protein family. This study successfully uncovered and analyzed the TXNDC17 gene in Scomber japonicus (SjTXNDC17).
View Article and Find Full Text PDFNitroxidative stress in human neural progenitor cells: In situ measurement of nitric oxide/peroxynitrite imbalance using metalloporphyrin nanosensors.
J Inorg Biochem
February 2025
Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. Electronic address:
Nitric oxide (NO) is an essential inorganic signaling molecule produced by constitutive NO synthase (cNOS) in the neurological system. Under pathological conditions, NO rapidly reacts with superoxide (O) to generate peroxynitrite (ONOO). Elevated ONOO concentrations induce nitroxidative stress, potentially contributing to numerous pathological processes as observed in neurodegenerative diseases including Alzheimer's disease (AD).
View Article and Find Full Text PDFendosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly .
bioRxiv
October 2024
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Tsetse flies ( spp.) vector African trypanosomes that cause devastating diseases in humans and domestic animals. Within the genus, species in the Palpalis subgroup exhibit greater resistance to trypanosome infections compared to those in the subgroup.
View Article and Find Full Text PDFShade-induced ROS/NO reinforce COP1-mediated diffuse cell growth.
Proc Natl Acad Sci U S A
October 2024
Fundación Instituto Leloir, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Bioquímicas de Buenos Aires, Buenos Aires 1405, Argentina.
Article Synopsis
- Canopy shade activates PHYTOCHROME INTERACTING FACTORS (PIFs), which boosts auxin synthesis in cotyledons, promoting hypocotyl growth for better light access.
- The study explores how shade influences cellular redox status and finds that high auxin levels under shade increase reactive oxygen species and nitric oxide in the hypocotyl.
- COP1, a positive growth regulator, is affected by redox regulation; when this mechanism is disrupted, it leads to poor hypocotyl growth coordination and reduced competitive ability against neighboring plants.
Sulindac prevents increased mitochondrial VDAC1 expression and cell surface mistargeting induced by pathological conditions in retinal cells.
Biochem Biophys Res Commun
December 2024
Department of Clinical Science, SUS, Division of Islet Cell Physiology, Lund University, Malmö, Sweden. Electronic address:
Diabetic retinopathy (DR) continues to be the primary cause of vision loss in poorly controlled diabetic subjects. The molecular mechanisms underlying retinal pigment epithelium (RPE) cell dysfunction in DR still remain elusive. We investigated the role of mitochondrial volt-age-dependent anion channel 1 (VDAC1) in RPE dysfunction under glucotoxic and inflammatory conditions.
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