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Cdr1 in focus: a personal reflection on multidrug transporter research.
FEMS Yeast Res
January 2025
Amity Institute of Integrative Science and Health, Amity University Haryana, Gurugram, 122413, India.
Drug resistance mechanisms in human pathogenic Candida species are constantly evolving. Over time, these species have developed diverse strategies to counter the effects of various drug classes, making them a significant threat to human health. In addition to well-known mechanisms such as drug target modification, overexpression, and chromosome duplication, Candida species have also developed permeability barriers to antifungal drugs through reduced drug import or increased efflux.
View Article and Find Full Text PDFRisk factor assessment for post-thrombolytic coronary angiogram normalcy in young myocardial infarction patients.
J Basic Clin Physiol Pharmacol
January 2025
Department of Clinical Pharmacology, 29988 JIPMER , Pondicherry, India.
Objectives: Acute myocardial infarction is a critical medical condition that poses a significant risk to life. It is distinguished by the abrupt cessation of blood flow to a specific segment of the cardiac muscle. Acute myocardial infarction accounts for more than 15 % of global mortality annually.
View Article and Find Full Text PDFMultiomics Analysis of Exportin Family Reveals XPO1 as a Novel Target for Clear Cell Renal Cell Carcinoma.
Int J Genomics
January 2025
Department of Medicine, Xinyang Vocational and Technical College, Xinyang, Henan, China.
Recently, exportin gene family members have been demonstrated to play essential roles in tumor progression. However, research on the clinical significance of exportin gene family members is limited in clear cell renal cell carcinoma (ccRCC). Pan-cancer data, ccRCC multiomics data, and single-cell sequence were included to analyze the differences in DNA methylation modification, single nucleotide variations (SNVs), copy number variations (CNVs), and expression levels of exportin gene family members.
View Article and Find Full Text PDFCaregiver perceptions of usual care home programs for persons with acquired brain injury: a qualitative descriptive study.
Front Rehabil Sci
January 2025
Department of Occupational Therapy, Duquesne University, Pittsburgh, PA, United States.
Objective: The study explores caregiver perceptions of home programs for clients with acquired brain injury based on current clinical care after transition to the community.
Design: A qualitative descriptive study.
Setting: Within the community, post inpatient rehabilitation.
Synergistic effects of quaternary ammonium compounds and antibiotics on the evolution of antibiotic resistance.
Water Res
January 2025
Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Key Laboratory of Water Pollution Control and Environmental Safety, Hangzhou, Zhejiang, 310058, China. Electronic address:
The usage of quaternary ammonium compounds (QACs) as disinfectants has surged dramatically during the COVID-19 pandemic and thereafter. QACs can promote antimicrobial resistance, but the combined effects of QACs and antibiotics in driving resistance evolution were yet revealed. This study aimed to evaluate antibiotic resistance of wastewater microorganisms under coexposure to typical antibiotics and the most widely used QAC, dodecyl dimethyl benzyl ammonium chloride (DDBAC).
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