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Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment.
Drug Discov Today
March 2025
Biotechnology Innovation Organization, Washington, DC, USA.
Sharing New Approach Methodology (NAM)-based regulatory experiences is crucial for improving human risk assessment and reducing animal use in drug safety testing. To foster broader adoption, the Biotechnology Innovation Organization surveyed companies about NAM usage and collected case studies showcasing NAM-based regulatory filings for biotherapeutics, where NAMs replaced large animal studies for safety assessment. These scientifically justified approaches were generally accepted by global health authorities, particularly in the context of species relevance limitations, prior target modulation experience, and/or when addressing severe disease.
View Article and Find Full Text PDFBuilding multi-professional UK partnerships and networks to improve access to palliative care for people experiencing homelessness.
Public Health Res (Southampt)
March 2025
Department of Health Sciences, Faculty of Science, University of York, York, UK.
Background: People experiencing homelessness have high rates of multi-morbidity and age-related conditions at a young age. Despite having high support needs, they have disparately low access to palliative care services and often die at a young age. To facilitate access to support for this group towards the end of life, a multi-professional approach should be taken.
View Article and Find Full Text PDFSeparation of left internal and external carotid arteries via right brachial artery approach in cerebral angiography.
Neuroradiol J
March 2025
Department of Neurosurgery, Ogaki Tokushukai, Ogaki, Japan.
Cerebral angiography is essential for diagnosing cerebrovascular diseases and crucial to separate the internal and external carotid arteries during angiography. The femoral artery approach is more invasive than the brachial artery approach. In some cases, guiding the catheter through the right brachial artery to the left internal and external carotid arteries is feasible.
View Article and Find Full Text PDFProcess evaluation of a complex intervention in augmentative and alternative communication care in Germany: a mixed methods study.
BMC Health Serv Res
March 2025
Department of Health Services Research, Faculty of Medicine and Health Sciences, Carl Von Ossietzky University of Oldenburg, Ammerlaender Heerstrasse 140, Oldenburg, 26129, Germany.
Background: In Germany, clear care pathways for people without natural speech who require augmentative and alternative communication (AAC) are currently lacking. Therefore, AAC is often not sustainably implemented in everyday life. For this reason, a complex intervention was developed that supplements existing AAC consultation with additional AAC training, AAC therapy, and case management.
View Article and Find Full Text PDFOpportunities and challenges in modelling ligand adsorption on semiconductor nanocrystals.
Commun Chem
March 2025
Department of Chemistry, Dartmouth College, 41 College St., Hanover, 03755, NH, USA.
Semiconductor nanocrystals, including their superstructures and hybridized systems, have opened up a new realm to design next-generation functional materials creatively. Their great success and unlimited potential should be largely attributed to surface-adsorbed ligands. However, due to a lack of means to probe and understand their roles in experiments, only a handful of effective ligands have been identified through trial-and-error processes.
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