Peptides of the allatostatin superfamily with the C-terminal amino acid sequence -YXFGL-NH2 have been isolated and identified from the lepidopterans, the codling moth, Cydia pomonella (Tortricidae) and the bollworm, Helicoverpa armigera (Noctuidae). The peptides, designated cydiastatins and helicostatins respectively, were monitored during purification with radioimmunoassays based on the callatostatins of the blowfly Calliphora vomitoria. The eight peptides from each of the two species appear to form an homologous series with four identical and three that differ by a single amino acid. This study demonstrates the ubiquitous nature of this family of peptides in insects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0196-9781(97)00188-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Machine learning-based rational design for efficient discovery of allatostatin analogs as promising lead candidates for novel IGRs.
Pest Manag Sci
November 2024
Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, P. R. China.
Article Synopsis
- Insect neuropeptide allatostatins (ASTs) are key regulators of growth and reproduction in insects, but their complex structures and production costs limit their use in pest management, prompting the need for shorter and cheaper AST analogs.
- This study applied machine learning techniques to identify crucial structural components that enhance the effectiveness of AST analogs, leading to the creation of six new compounds, with one (A53) showing exceptional potency compared to natural variants.
- The findings highlight how computational methods can streamline the design and evaluation of novel AST analogs as potential insect growth regulators, providing a strategic approach for improving pest control.
Global analysis of neuropeptide receptor conservation across phylum Nematoda.
BMC Biol
October 2024
Animal Physiology and Neurobiology, Department of Biology, University of Leuven (KU Leuven), Naamsestraat 59, 3000, Leuven, Belgium.
Background: The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and numerous behaviors, and they represent appealing pharmacological targets for parasite control. Efforts are ongoing to characterize the functions and define the ligands of nematode GPCRs, with already most peptide GPCRs known or predicted in Caenorhabditis elegans.
View Article and Find Full Text PDFThe complex neurochemistry of the cockroach antennal heart.
Cell Tissue Res
November 2024
Department of Biology II (Zoology), RWTH Aachen University, Worringerweg 3, 52074, Aachen, Germany.
The innervation of the antennal heart of the cockroach Periplaneta americana was studied with immunocytochemical techniques on both the light and electron microscopic levels. The antennal heart is innervated by two efferent systems, both using one biogenic amine in combination with neuropeptides. In one, we found co-localization of serotonin with proctolin and allatostatin.
View Article and Find Full Text PDFMechanisms controlling haemolymph circulation under resting conditions in the Chagas disease vector Rhodnius prolixus.
J Exp Biol
August 2024
Cátedra de Histología y Embriología Animal, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, 1900 La Plata, Buenos Aires, Argentina.
Chagas disease vectors can ingest several times their own volume in blood with each meal. This ad libitum feeding causes an intense process of diuresis, inducing the insect to eliminate a large quantity of urine and faeces. To ensure diuresis, the speed of circulation of the haemolymph is increased.
View Article and Find Full Text PDFEndocrine Control of Lipid Metabolism.
Adv Exp Med Biol
May 2024
Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS, USA.
Lipids are essential in insects and play pleiotropic roles in energy storage, serving as a fuel for energy-driven processes such as reproduction, growth, development, locomotion, flight, starvation response, and diapause induction, maintenance, and termination. Lipids also play fundamental roles in signal transduction, hormone synthesis, forming components of the cell membrane, and thus are essential for maintenance of normal life functions. In insects, the neuroendocrine system serves as a master regulator of most life activities, including growth and development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!