Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1086/BBLv193n2p203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mast cell-mediated microRNA functioning in immune regulation and disease pathophysiology.
Clin Exp Med
January 2025
The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Upon stimulation and activation, mast cells (MCs) release soluble mediators, including histamine, proteases, and cytokines. These mediators are often stored within cytoplasmic granules in MCs and may be released in a granulated form. The secretion of cytokines and chemokines occurs within hours following activation, with the potential to result in chronic inflammation.
View Article and Find Full Text PDFProbing the Histamine H Receptor Binding Site to Explore Ligand Binding Kinetics.
J Med Chem
January 2025
Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Analysis of structure-kinetic relationships (SKR) can contribute to an improved understanding of receptor-ligand interactions. Here, fragment (4-(2-benzylphenoxy)-1-methylpiperidine) was used in different fragment growing approaches to mimic the putative binding mode of the long residence time (RT) ligands olopatadine, acrivastine, and levocetirizine at the histamine H receptor (HR). SKR analyses reveal that introduction of a carboxylic acid moiety can increase RT at HR up to 11-fold.
View Article and Find Full Text PDFUsing a chronic unpredictable mild stress (CUMS) combined with multi-platform water environment sleep deprivation (SD) as an animal model, the occurrence and development of human depression combined with insomnia were simulated. The abnormal mitochondrial autophagy signaling caused by the putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) signaling pathway directly affects the normal secretion of melatonin by the pineal gland, which may explain the pathogenesis of depression combined with insomnia. This study aims to explore the depression-like behavior, sleep changes, central oxidative stress response, pineal mitochondrial autophagy damage, melatonin secretion, histopathological changes of the pineal gland, and the expression of Pink1/Parkin signaling-related factors in CUMS+SD rats.
View Article and Find Full Text PDFNeoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer.
J Ovarian Res
September 2024
Program in Women's Oncology, Women and Infants Hospital, Providence, RI, USA.
Article Synopsis
- High grade serous ovarian cancer (HGSOC) is a deadly gynecologic cancer that shows limited response to existing immunotherapies, highlighting the need for new immune targets, particularly focusing on the role of mast cells which increase after chemotherapy treatment.
- The study utilized immunohistochemistry methods to analyze mast cell levels in 36 HGSOC patient tumors before and after neoadjuvant chemotherapy (NACT), revealing significant changes in mast cell populations and their association with clinical outcomes.
- Results indicated that higher mast cell levels post-NACT were linked to poorer patient survival outcomes, with specific forms of mast cells (Tryptase+/CPA3+) showing a strong correlation with overall survival rates.
Pharmacological characterization of the zebrafish Hrh2a histamine H receptor.
Eur J Pharmacol
October 2024
Amsterdam Institute for Molecules, Medicines, and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands. Electronic address:
The zebrafish, Danio rerio, is a widely adopted in vivo model that conserves organs such as the liver, kidney, stomach, and brain, being, therefore, suitable for studying human diseases, drug discovery and toxicology. The brain aminergic systems are also conserved and the histamine H, H and H receptors were previously cloned and identified in the zebrafish brain. Genome studies identified another putative H receptor (Hrh2) with ∼50% sequence identity with H receptor orthologs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!