Scientists have been dissecting the neural architecture of the human mind for several centuries. Dissecting its computational architecture has proven more difficult, however. Within the cognitive sciences, for example, there is a debate about the extent to which human reasoning is generated by computational machinery that is domain specific and functionally specialized. While some claim that the same set of cognitive processes accounts for reasoning across all domains (e.g. Rips 1994, Johnson-Laird & Byrne 1991), others argue that reasoning is generated by several different mechanisms, each designed to operate over a different class of content (e.g. Baron-Cohen 1995, Cheng & Holyoak 1985, Cosmides & Tooby 1992, Leslie 1987). Indeed, it has recently been proposed that the human cognitive architecture contains a faculty of social cognition; a suite of integrated mechanisms, each of which is specialized for reasoning and making decisions about a different aspect of the social world. Candidate devices include a theory of mind mechanism, an eye direction detector, social contract algorithms, permission schemas, obligation schemas, precaution rules, threat detection procedures and others (e.g. Baron-Cohen 1995, Cheng & Holyoak 1985, Cosmides 1985, 1989, Cosmides & Tooby 1989, 1992, 1994, Fiddick et al 1995, Fiske 1991, Jackendoff 1992, Leslie 1987, K. Manktelow & D. Over, unpublished paper, 1st Int Conf on Thinking, Plymouth, UK 1988, Manktelow & Over 1990, M.Rutherford, J. Tooby, L. Cosmides, unpublished paper, 8th Annual Meeting Human Behav Evol Society, Northwestern Univ, IL 1996, J. Tooby & L. Cosmides, unpublished paper, 2nd Annual Meeting Human Behav Evol Society, Evanston, IL 1989). To decide among these sometimes competing proposals, psychologists need empirical methods and theoretical standards that let us carve social inference mechanisms at the joints. We will argue that the theoretical standards needed are those of the 'adaptationist programme' developed in evolutionary biology. To show how these standards can be applied in dissecting the computational architecture of the human mind, we will discuss some recent empirical methods and results.
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http://dx.doi.org/10.1002/9780470515372.ch8 | DOI Listing |
Sci Rep
January 2025
University of Ulsan, 93 Daehak-ro, Nam-gu, Ulsan, 680-749, Republic of Korea.
This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
January 2025
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China; Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing 100044, China; National Center for Trauma Medicine, Peking University People's Hospital, Beijing 100044, China. Electronic address:
Objective: The bare area is defined as a transverse region within the trochlear notch, serving as an optimal entry point for olecranon osteotomy due to the absence of articular cartilage coverage. However, there is limited research on the morphology and location of the bare area, and there is a lack of intuitive visual description. Thus, the purpose of this study is to delineate anatomical features of the bare area and visualize its morphology and refine the olecranon osteotomy approach.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg
January 2025
Department of Cardiovascular Surgery, Nerima Hikarigaoka Hospital, 1-5-2, Hikarigaoka, Nerima-ku, Tokyo, Japan.
Objective: Branched prostheses are used to treat aortic arch with dissection. However, changes in the neck vessel geometry and diameter after dissection are not well known. We aimed to evaluate neck vessels geometry and changes in diameter with dissection.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca (USAL) & Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.
There are many different cells that perform highly specialized functions in the human hematological and immune systems. Due to the relevance of their activity, in this work we investigated the cell types and subtypes that form this complex system, using single-cell RNA sequencing (scRNA-seq) to dissect and assess the markers that best define each cell population. We first developed an optimized computational workflow for analyzing large scRNA-seq datasets.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and School of Life Sciences, Yunnan University, Kunming 650091, China.
The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-binding cavity (SBC), suggesting noncompetitive inhibition.
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