A 57-year-old corporate executive, married with three grown children, began suffering from severe flu-like symptoms and weight loss. Hospitalized for a week, he was tested for chronic fatigue syndrome and mononucleosis. Finally, with no change in his symptoms, his physician recommended an HIV test. The results were positive.
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Mol Med Rep
March 2025
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Most psychiatric disorders are heterogeneous and are attributed to the synergistic action of a multitude of factors. It is generally accepted that psychiatric disorders are the outcome of interactions between genetic predisposition and environmental perturbations, which involve psychosocial stress, or alterations in the physiological state of the organism. A number of hypotheses have been presented on such environmental influences that may include direct insults such as injury, malnutrition and hostile living conditions, or indirect sequelae following infection from viruses such as influenza, arboviruses, enteroviruses and several herpesviruses, or the differential expression of human endogenous retroviruses.
View Article and Find Full Text PDFHealth Expect
December 2024
Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.
Background: Disorders of consciousness (DoC) refers to a group of clinical conditions of altered consciousness. To improve their diagnosis and prognosis, multimodal assessment can be of great importance. Informal caregivers of people with DoC who are confronted with new technologies as such can benefit from interventions to expand their health literacy, i.
View Article and Find Full Text PDFJ Midlife Health
October 2024
Department of Bioengineering, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Ovarian cancer presents significant challenges in clinical oncology due to its high prevalence, heterogeneity, and late-stage diagnosis. Our study explores the application of single-cell RNA sequencing (scRNA-Seq) and bulk RNA sequencing to enhance our understanding of ovarian cancer at the molecular level. We highlight the diagnostic strategies and emphasize the critical role of scRNA-Seq in unraveling the intricate cellular composition and phenotypic plasticity within ovarian tumors.
View Article and Find Full Text PDFBiology (Basel)
November 2024
Unité de Biologie Moléculaire, Hôpital Général de Peltier, Centre Hospitalier Universitaire de Djibouti, Avenue Marechal, Djibouti ville 98230, Djibouti.
Djibouti is confronted with malaria resurgence, with malaria having been occurring in epidemic proportions since a decade ago. The current epidemiology of drug-resistant is not well known. Molecular markers were analyzed by targeted sequencing in 79 clinical isolates collected in Djibouti city in 2023 using the Miseq Illumina platform newly installed in the country.
View Article and Find Full Text PDFInt J Surg Pathol
November 2024
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
() amplification via fluorescence in-situ hybridization (FISH) is the gold standard test used for confirming the diagnosis of atypical lipomatous tumor/well differentiated liposarcoma and dedifferentiated liposarcoma. It is also used as a screening test in high grade spindle cell or pleomorphic neoplasms. FISH is considered positive for amplification when the /CEP12 ratio is greater than 2; however, a ratio between 2 and 3 is considered a "low-level" amplification and raises the possibility of a false positive result; thus, posing a diagnostic dilemma.
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