[Lipid peroxidation in patients with hypertension and renal hypertension against a background of diabetes mellitus].

Time course of changes was studied in parameters characterizing lipid peroxidation (LPO) and the total lipids counts in red cell membranes (RCM) and blood plasma (BP) of patients with hypertensive disease (HD) and arterial hypertension in chronic pyelonephritis against the background of diabetes mellitus (DM). The study groups were DM patients (group I), those with coexistent HDDM (group II), and those with arterial hypertension caused by chronic pyelonephritis in the presence of DM (group III). All three groups of patients demonstrated intensification of the cellular membrane- and blood plasma LPO as well as increase in the total lipids counts. HDDM results in much higher levels of the RCM and BP LPO products. Relatively higher RCM and BP LPO in group II patients as compared with III one, permits differentiating the above pathologic mixes. The results obtained allow us to recommend that antioxidants be incorporated into a complex therapy to be adopted for treating the above conditions.