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Novel role of folate (vitamin B9) released by fermenting bacteria under Human Intestine like environment.
Sci Rep
November 2023
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
The anaerobic region of the gastrointestinal (GI) tract has been replicated in the anaerobic chamber of a microbial fuel cell (MFC). Electroactive biomolecules released by the facultative anaerobes (Providencia rettgeri) under anoxic conditions have been studied for their potential role for redox balance. MALDI study reveals the presence of vitamin B9 (folate), 6-methylpterin, para-aminobenzoic acid (PABA) and pteroic acid called pterin pool.
View Article and Find Full Text PDFNovel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications.
Biomedicines
September 2023
Department of Medical Education, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
A "building block" is a key component that plays a substantial and critical function in the pharmaceutical research and development industry. Given its structural versatility and ability to undergo substitutions at both the amino and carboxyl groups, para-aminobenzoic acid (PABA) is a commonly used building block in pharmaceuticals. Therefore, it is great for the development of a wide range of novel molecules with potential medical applications.
View Article and Find Full Text PDFHybrid PABA-glutamic acid conjugated 1,3,5-triazine derivatives: Design, synthesis, and antimalarial activity screening targeting Plasmodium falciparum dihydro folate reductase enzyme.
Chem Biol Drug Des
December 2023
RMRC-ICMR NE Region, Dibrugarh, Assam, India.
Despite the successful reduction in the malaria health burden in recent years, it continues to remain a significant global health problem mainly because of the emerging resistance to first-line treatments. Also because of the disruption in malaria prevention services during the COVID-19 pandemic, there was an increase in malaria cases in 2021 compared to 2020. Hence, the present study outlined the in silico study, synthesis, and antimalarial evaluation of 1,3,5-triazine hybrids conjugated with PABA-glutamic acid.
View Article and Find Full Text PDFGreen synthesized Ag nanoparticles stimulate gene expression and paclitaxel production in Corylus avellana cells.
Appl Microbiol Biotechnol
October 2023
Department of Plant Production and Genetics, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
Synthesis of nanoparticles (NPs) through plant extracts has been suggested as an effective and nature-friendly method. Paclitaxel is one of the most valuable secondary metabolites with therapeutic uses, and hazelnut has been suggested as one of the sustainable resources for producing this metabolite. In the present study, we synthesized Ag NPs using the ethanolic extract of C.
View Article and Find Full Text PDF[A complex of B vitamins, choline and inosine in the treatment of chronic pain].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2023
Pirogov Russian National Research Medical University, Moscow, Russia.
Chronic pain is an independent disease associated with multiple changes in the nervous, endocrine and immune systems. The use of B vitamins is pathogenetically justified. Unlike others, the CompligamB complex contains almost all fractions of B vitamins, inosine and para-aminobenzoic acid, which provides an additional therapeutic effect.
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