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Perioperative Anesthetic Considerations for Catheter-Based Pulmonary Vein Interventions in Fibrosing Mediastinitis.
J Cardiothorac Vasc Anesth
December 2024
Department of Cardiothoracic Anesthesiology, Cleveland Clinic, Cleveland, OH. Electronic address:
Introduction: Fibrosing mediastinitis (FM) is a rare disease characterized by abnormal proliferation of fibrous tissue, causing compression and narrowing of the airway, blood vessels, and other mediastinal structures, including the pulmonary veins. Catheter-based interventions are available as palliative strategies. Due to the complex nature of the disease and the profound respiratory and hemodynamic sequelae that may ensue, anesthetic management requires meticulous interdisciplinary planning.
View Article and Find Full Text PDFThe Not-So-Benign Sickle Cell Trait: A Case of Renal Medullary Carcinoma.
J Community Hosp Intern Med Perspect
May 2024
Greater Baltimore Medical Center, Towson, MD, USA.
Sickle cell trait (SCT) has long been considered a benign carrier state with malarial protection, but carriers can be affected by increased venous thromboembolism, exercise-related injury, renal complications and very rarely a fatal renal malignancy. Renal medullary carcinoma is a very rare and aggressive renal tumor described almost exclusively in sickle cell trait. A review of the current literature provides clues to this link and describes trends expected in these cases.
View Article and Find Full Text PDFPredicting human half-life for insulin analogs: An inter-drug approach.
Eur J Pharm Biopharm
August 2024
Global Drug Discovery, Research & Early Development, Novo Nordisk, DK-2760 Måløv, Denmark. Electronic address:
An inter-drug approach, applying pharmacokinetic information for insulin analogs in different animal species, rat, dog and pig, performed better compared to allometric scaling for human translation of intra-venous half-life and only required data from a single animal species for reliable predictions. Average fold error (AFE) between 1.2-1.
View Article and Find Full Text PDFProtracted metallogenic and magmatic evolution of the Kirazlı epithermal Au-Ag and porphyry Cu deposits, Biga Peninsula, NW Turkey: evidence from zircon U-Pb, muscovite Ar/Ar, and molybdenite Re-Os geochronology.
Miner Depos
December 2023
Department of Earth Sciences, Mineral Resources and Geofluids, University of Geneva, 1206 Geneva, Switzerland.
Unlabelled: The Kirazlı deposit is located at the center of the Biga Peninsula metallogenic province, in a geological setting characterized by an extensional tectonic environment. A NNW-SSE trending high-sulfidation (HS) orebody with a total reserve of 33.86 Mt @ 0.
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