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The Beneficial Role of the Thyroid Hormone Receptor Beta 2 () in Facilitating the First Feeding and Subsequent Growth in Medaka as Fish Larval Model.
Cells
March 2025
College of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan 430070, China.
During the early growth stages of fish larvae, there are significant challenges to their viability, so improving their visual environment is essential to promoting their growth and survival. Following the successful knockout of thyroid hormone receptor beta 2 () using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology, there was an increase in the expression of UV opsin (short-wave-sensitive 1, ), while the expression of other cone opsins was significantly decreased. Further analysis of the retinal structure demonstrated that the knockout resulted in an increased lens thickness and a decreased thickness of the ganglion cell layer (GCL), outer plexiform layer (OPL), and outer nuclear layer (ONL) in the retina.
View Article and Find Full Text PDFTestosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism.
J Cachexia Sarcopenia Muscle
February 2025
Center for Translational Research on Inflammatory Diseases, Michael E DeBakey VA Medical Center, Houston, Texas, USA.
Background: Testosterone replacement therapy (TRT) added to lifestyle therapy can mitigate weight-loss-induced reduction of muscle mass and bone mineral density (BMD) in older men with obesity and hypogonadism.
Objective: To investigate the molecular mechanisms underlying the attenuation of muscle and BMD loss in response to TRT during intensive lifestyle intervention in this high-risk older population.
Methods: Among 83 older (≥ 65 years) men with obesity (BMI ≥ 30 kg/m) and hypogonadism (early AM testosterone persistently < 300 ng/dL) associated with frailty (Modified Physical Performance Test score ≤ 31) randomized into 26-week lifestyle therapy plus testosterone (LT+TRT) or placebo (LT+Pbo) in the LITROS trial, 38 underwent serial muscle biopsies for the muscle transcriptomics substudy.
Histology and histochemistery of the thyroid gland in three post-hatching development Egyptian Baladi chickens (Gallus G. domesticus): Novel insights of thyroid hormone levels with special insights regarding bone formation.
Tissue Cell
June 2025
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
The thyroid gland is an essential endocrine organ that regulates the body's metabolic rate, helps maintain the body's weight, and supports the development of various body organs. Our research is a novel effort to examine the histomorphometric features of the thyroid gland and its relationship with the bone formation of three post-hatching development age stages of Baladi chickens: juvenile (fourteen days old), immature (two months), and mature (six months). This study employs histology, histochemistry, and analysis of thyroid hormone levels.
View Article and Find Full Text PDFInterspecies Blastocyst Complementation and the Genesis of Chimeric Solid Human Organs.
Genes (Basel)
February 2025
Molecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
Solid organ transplantation remains a life-saving treatment for patients worldwide. Unfortunately, the supply of donor organs cannot meet the current need, making the search for alternative sources even more essential. Xenotransplantation using sophisticated genetic engineering techniques to delete and overexpress specific genes in the donor animal has been investigated as a possible option.
View Article and Find Full Text PDFImpaired olfactory bulb neurogenesis mediated by Notch1 contributes to olfactory dysfunction in mice chronically exposed to methamphetamine.
Cell Biol Toxicol
February 2025
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China.
Methamphetamine (Meth) is a potent central nervous system stimulant with high addictive potential and neurotoxic effects. Chronic use results in significant damage in various brain functions, including cognition, memory, and sensory perception. Olfactory dysfunction is a notable yet often overlooked consequence of Meth abuse, and its underlying mechanisms are not fully understood.
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