The incidence of Down's syndrome was studied in 1870 infants of diabetic mothers out of 22,300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for diabetes and all cases of Down's syndrome were confirmed by chromosome analysis. Down's syndrome (all trisomy 21) was diagnosed in 35 infants: seven were born to mothers with gestational diabetes and 28 to non-diabetic mothers. The incidence of Down's syndrome was higher in infants of diabetic mothers (3.75 per 1000 v 1.36 per 1000) (p = 0.02) with a relative risk of 2.75. No significant difference was found in maternal age between both groups (p = 0.67) and the rate of Down's syndrome was higher in infants of diabetic mothers when compared with infants of non-diabetic mothers of similar age. Down's syndrome should be added to the congenital malformations already known to occur more frequently in infants of diabetic mothers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717320 | PMC |
| http://dx.doi.org/10.1136/adc.77.3.242 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Periodontal diseases in Down syndrome during childhood: a scoping review.
BMC Oral Health
January 2025
Université Paris Cité, Laboratory URP 2496 Orofacial Pathologies, Imaging, and Biotherapies, Faculty of odontology, Montrouge, France.
Background: Down syndrome (DS) is a genetic condition that involves the deregulation of immune function and is characterized by a proinflammatory phenotype leading to an impaired response to infections. Periodontitis is a highly prevalent chronic inflammatory disease. It has been shown that adults and teenagers with DS are more susceptible to this disease, but a similar correlation in DS children remains elusive.
View Article and Find Full Text PDFWeight Trajectories among Children with Down Syndrome: A Retrospective Chart Review.
J Pediatr
January 2025
Children's Mercy Kansas City, Kansas City, Missouri; University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri; Center for Children's Healthy Lifestyles and Nutrition, Kansas City, Missouri.
Objectives: To evaluate body mass index (BMI) trajectories over time and to evaluate common comorbidities across a large, nationally representative sample of youth with Down syndrome (DS) STUDY DESIGN: This retrospective study included children ages 2 through18 years within the Cerner Health Facts database with a diagnosis of DS and a medical visit between 2010 and 2017. Comorbid conditions were mapped into PheCodes (ie, one or more ICD codes that combine into specific diseases or traits) and were included if they occurred in at least 1% (145 PheCodes) of the sample.
Results: Outcomes trajectories were analyzed through generalized additive mixed models.
Comparison of Unaided and Aided Visual Acuity in Adults With Down Syndrome.
Transl Vis Sci Technol
January 2025
The Ohio State University College of Optometry, Columbus, OH, USA.
Purpose: Individuals with Down syndrome (DS) have reduced visual acuity (VA), even when wearing refractive correction. The relationship between refractive error and VA in adults with DS is explored.
Methods: Thirty adults with DS (age = 29 ± 10 years) were enrolled in a trial comparing clinical and objectively determined refractions.
Epigenetic Control of Hyperuricemia and Gout by Gene Writer DNMT1 and RNA Editor ADAR1: Mechanism of Gout and Amyloid Dissolution in Down Syndrome.
Biochem Genet
January 2025
Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Although DNA methyltransferase 1 (DNMT1) and RNA editor ADAR triplications exist in Down syndrome (DS), their specific roles remain unclear. DNMT methylates DNA, yielding S-adenosine homocysteine (SAH), subsequently converted to homocysteine (Hcy) and adenosine by S-adenosine homocysteine (Hcy) hydrolase (SAHH). ADAR converts adenosine to inosine and uric acid.
View Article and Find Full Text PDFFirst trimester cervical angles for the prediction of spontaneous preterm birth.
Eur J Obstet Gynecol Reprod Biol
January 2025
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
Objective: First trimester cervical angles for the prediction of spontaneous preterm birth (sPTB) remains unclear. The objective is to explore the potential value of first trimester cervical angles for the prediction of sPTB.
Study Design: This was a secondary analysis of data derived from a prospective cohort study for sPTB screening in singleton pregnancies at 11 + 0-13 + 6 weeks in women attending routine Down's syndrome screening at Prince of Wales Hospital, Hong Kong SAR, between June 2018 and July 2020.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!