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People and Pixels 20 years later: the current data landscape and research trends blending population and environmental data.
Popul Environ
December 2019
Department of Geography, Environmental Sciences, and Marine Resource Management, Oregon State University, Corvallis, USA.
In 1998 the National Research Council published . The volume focused on emerging research linking changes in human populations and land use/land cover to shed light on issues of sustainability, human livelihoods, and conservation, and led to practical innovations in agricultural planning, hazard impact analysis, and drought monitoring. Since then, new research opportunities have emerged thanks to the growing variety of remotely sensed data sources, an increasing array of georeferenced social science data, including data from mobile devices, and access to powerful computation cyberinfrastructure.
View Article and Find Full Text PDFPress-Fit Bone-Anchored Prosthesis for Individuals with Transtibial Amputation.
JBJS Essent Surg Tech
May 2024
Radboud University Medical Center, Nijmegen, The Netherlands.
Background: This video article describes the use of bone-anchored prostheses for patients with transtibial amputations, most often resulting from trauma, infection, or dysvascular disease. Large studies have shown that about half of all patients with a socket-suspended artificial limb experience limited mobility and limited prosthesis use because of socket-related problems. These problems occur at the socket-residual limb interface as a result of a painful and unstable connection, leading to an asymmetrical gait and subsequent pelvic and back pain.
View Article and Find Full Text PDFPeripheral Nerve Stimulation for Chronic Neuropathic Pain: A Health Technology Assessment.
Ont Health Technol Assess Ser
January 2025
Background: Chronic neuropathic pain is a major health problem that adversely affects people's physical and mental well-being, as well as their quality of life. Percutaneous peripheral nerve stimulation (PNS) may offer a minimally invasive option earlier in the treatment continuum for adults with chronic neuropathic pain that is refractory to conventional medical management. We conducted a health technology assessment of PNS for adults with chronic neuropathic pain, which included an evaluation of effectiveness, safety, cost-effectiveness, the budget impact of publicly funding PNS, and patient preferences and values.
View Article and Find Full Text PDFTwo-stage diffuse fluorescence tomography for monitoring of drug distribution in photodynamic therapy of tumors.
J Biomed Opt
January 2025
Lund University, Department of Physics, Lund, Sweden.
Significance: The spatial distribution of the photosensitizing drug concentration is an important parameter for predicting the photodynamic therapy (PDT) outcome. Current diffuse fluorescence tomography methods lack accuracy in quantifying drug concentration. The development of accurate methods for monitoring the temporal evolution of the drug distribution in tissue can advance the real-time light dosimetry in PDT of tumors, leading to better treatment outcomes.
View Article and Find Full Text PDFAdeno-associated viral vectors for modeling Parkinson's disease in non-human primates.
Neural Regen Res
January 2025
CNS Gene Therapy Department, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor, but extremely challenging. Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials. While these failures have many possible explanations, it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.
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