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Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy.
Invest New Drugs
February 2000
Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA, USA.
Angiogenesis, the formation of new blood vessels from an existing vasculature, is requisite for tumor growth. It entails intercellular coordination of endothelial and tumor cells through angiogenic growth factor signaling. Interruption of these events has implications in the suppression of tumor growth.
View Article and Find Full Text PDFSuramin keratosis: a unique skin eruption in a patient receiving suramin for metastatic prostate cancer.
J Urol
December 1997
Dermatology Services, Walter Reed Army Medical Center, Washington, D.C. 20307-5001, USA.
Cutaneous eruptions from suramin. A clinical and histopathologic study of 60 patients.
Arch Dermatol
October 1995
Department of Dermatology, University of Maryland Cancer Center, Baltimore, USA.
Background And Design: During a trial of suramin for advanced solid tumors, a high rate of cutaneous adverse reactions was observed. We present a prospective study, describing the clinical, histopathologic, histochemical, and immunochemical findings of the cutaneous reactions observed in 60 patients treated with suramin.
Results: Forty-nine (82%) of the 60 patients studied experienced at least one cutaneous reaction attributable to suramin therapy.
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