Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/a:1018851425080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Regulatory roles of eugenol in paraquat-altered SNCA/LZTS3/MAPT in the cerebellum of Wistar rats.
Lab Anim Res
January 2025
Anatomy Department, Faculty of Basic Medical Sciences, Alex Ekwueme, Federal University, Ndufu-Alike, Ebonyi State, Nigeria.
Background: The Microtubules-associated protein tau (MAPT), alpha-synuclein (SNCA), and leucine zipper tumor suppressor 3 (LZTS3) genes are implicated in neurodegeneration and tumor suppression, respectively. This study investigated the regulatory roles of eugenol on paraquat-altered genes.
Results: Forty male Wistar rats divided into five groups of eight rats were used.
Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.
Analyst
January 2025
Physics Department, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallès, Barcelona, Spain.
Radioresistant tumours remain complex to manage with current radiotherapy (RT) techniques. Heavy ion beams were proposed for their treatment given their advantageous radiobiological properties. However, previous studies with patients resulted in serious adverse effects in the surrounding healthy tissues.
View Article and Find Full Text PDFMethotrexate Crystals on Electron Microscopy of Kidney Biopsy for Acute Kidney Injury.
Kidney Med
December 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
Article Synopsis
- - A case of acute kidney injury related to high-dose methotrexate therapy in a patient with primary central nervous system lymphoma is presented, highlighting its rarity in such treatments.
- - The patient experienced high serum methotrexate levels shortly after the drug infusion, which led to the development of acute kidney injury, necessitating a kidney biopsy.
- - The biopsy revealed methotrexate crystals for the first time using toluidine blue staining and transmission electron microscopy, providing new insights into their ultrastructural characteristics.
Manifestation of the FLASH effect in proton irradiation of embryos.
Int J Radiat Biol
December 2024
Institute for Nuclear Research, Russian Academy of Sciences (INR RAS), Troitsk, Russia.
Purpose: In order to study the FLASH effect using live models, this work compared proton-induced damage to embryos (nine days after fertilization) and one-day-old chicks (18 days after fertilization) from irradiated at different dose rates eggs of Japanese quail ().
Materials And Methods: Eggs were irradiated with protons in different modes depending on the dose rate: in a conventional mode (<1 Gy/s, CONV), in a flash mode (∼100 Gy/s, FLASH) and in a single-pulse flash mode (∼10 Gy/s SPLASH).
Results: By the criteria of body weight and length, as well as the number of erythrocytes with micronuclei in nine-day-old embryos from eggs irradiated in the spread-out Bragg peak (SOBP) (8.
The therapeutic effect and underlying biochemical mechanism of methylprednisolone and D-methionine in "rescuing" noise-induced hearing loss in guinea pigs.
Hear Res
December 2024
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Objectives: Currently, there are no approved therapeutics for noise-induced hearing loss (NIHL). Both oxidative stress and cochlear inflammation play important roles in the mechanism of NIHL. In this study, we evaluate the effect of D-methionine (D-met) and methylprednisolone (MP) on noise-induced hearing loss of guinea pigs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!