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Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders.
Int J Mol Sci
December 2024
Department of Anatomy, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Neuroimmunology is reshaping the understanding of the central nervous system (CNS), revealing it as an active immune organ rather than an isolated structure. This review delves into the unprecedented discoveries transforming the field, including the emerging roles of microglia, astrocytes, and the blood-brain barrier (BBB) in orchestrating neuroimmune dynamics. Highlighting their dual roles in both repair and disease progression, we uncover how these elements contribute to the intricate pathophysiology of neurodegenerative diseases, cerebrovascular conditions, and CNS tumors.
View Article and Find Full Text PDFTruncated TrkB: The predominant TrkB Isoform in Nociceptors.
bioRxiv
December 2024
Center for Pain Therapeutics and Addiction Research, School of Dentistry, University of Texas Health San Antonio, Texas, 78229, USA.
Truncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, sensory neuronal TrkB expression and function has been traditionally associated with non-nociceptive neurons, particularly Aδ low-threshold mechanoreceptors. This study challenges prevailing assumptions by demonstrating that TrkBT1 is the predominant TrkB isoform expressed in sensory neurons and plays a functional role in modulating neuronal activity.
View Article and Find Full Text PDFUnderstanding the National Healthcare Ecosystem to Position Medical Affairs as a Strategic Element: Lessons Learned from AstraZeneca Spain.
Pharmaceut Med
December 2024
Medical Affairs Department, AstraZeneca Farmacéutica Spain, C. del Puerto de Somport 21-23, Fuencarral-El Pardo, 28050, Madrid, Spain.
Introduction: The rapidly evolving healthcare landscape has prompted Medical Affairs (MA) departments within pharmaceutical companies to transition from their traditional role as information providers to becoming strategic partners in the healthcare ecosystem. Responding to the increasing complexity of patient needs and stakeholder dynamics within Spain's national health system, this shift emphasizes the importance of aligning MA functions with broader healthcare goals. Effective transformation requires in-depth assessments of stakeholder trends and expectations.
View Article and Find Full Text PDFDisruptive diversity: Exploring racial commodification in the Norwegian cultural field.
Br J Sociol
December 2024
Department of Sociology and Human Geography, University of Oslo, Oslo, Norway.
Scholars have suggested that the heightened focus on diversity in Western cultural fields may drive forms of racial commodification, impacting cultural representations of 'race'. However, few studies apply Bourdieu's theory of cultural production to understand how racial commodification may also disrupt field dynamics. This article aims to explore how racialised minority cultural producers in Norway experience the intensified focus on diversity within the cultural field.
View Article and Find Full Text PDFEnergy-Efficient Integrated Electro-Optic Memristors.
Nano Lett
December 2024
Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, U.K.
Neuromorphic photonic processors are redefining the boundaries of classical computing by enabling high-speed multidimensional information processing within the memory. Memristors, the backbone of neuromorphic processors, retain their state after programming without static power consumption. Among them, electro-optic memristors are of great interest, as they enable dual electrical-optical functionality that bridges the efficiency of electronics and the bandwidth of photonics.
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