AI Article Synopsis
- Both 2-nitrooxymethyl-4-phenyl- and 4-nitrooxymethylphenyl-1,4-dihydropyridines are new compounds combining two vasodilating structures, but 2 could not be isolated due to rapid lactonization.
- Derivatives of 4-nitrooxymethylphenyl-1,4-dihydropyridines were synthesized using a method involving nitrooxymethylated benzaldehydes, and their effects were tested on porcine trabecular muscles and coronary arteries.
- While the compounds were found to have negative inotropic effects compared to nitrendipine, they demonstrated less vasodilator activity than both nitrend
Article Abstract
Both 2-nitrooxymethyl-4-phenyl- (2) and 4-nitrooxymethylphenyl-1,4-dihydropyridines (3) represent new combinations of two different vasodilating structures. 2 could not be isolated due to its spontaneous lactonization. Derivatives of 3 were obtained via Hantzsch synthesis using nitrooxymethylated benzaldehydes. The inotropic potency in isolated porcine trabecular muscles and the vasodilator activity in isolated porcine coronary arteries of four nitrooxyphenyl-dihydropyridines were determined. Nitrendipine (NTD) and glyceryl trinitrate (GTN) were used for reference. 3 were negative inotropic, however, less than NTD and--except for the dicyano derivative 3d--more than GTN. Vasodilator properties were less pronounced than that of both nitrendipine and GTN. Vascular selectivity was low.
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| http://dx.doi.org/10.1002/ardp.19973300804 | DOI Listing |
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