Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.

J Antibiot (Tokyo)

Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355, USA.

Published: September 1997

A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.

Download full-text PDF

Source
http://dx.doi.org/10.7164/antibiotics.50.729DOI Listing

Publication Analysis

Top Keywords

atp-citrate lyase
8
antimycins
4
antimycins inhibitors
4
inhibitors atp-citrate
4
lyase streptomyces
4
streptomyces group
4
group compounds
4
compounds belonging
4
belonging antimycin
4
antimycin class
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!