A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.7164/antibiotics.50.729 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!