Multiple stress fractures in the same bone are a rare occurrence. This paper presents an unusual case of a 19-year-old, healthy man who sustained a pathologic fracture of the proximal tibia through a stress-fracture site. The radiographic examination of the tibia also revealed multiple stress fractures inferior to the pathologic fracture. Magnetic resonance imaging can be used to rule out neoplasm and to confirm the stress-fracture diagnosis. Multiple stress fractures in the same bone can be treated with cast immobilization.
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Matern Child Health J
January 2025
Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA.
Objective: Development of postpartum depressive symptoms (PDS) is influenced by many social determinants of health, including income, discrimination, and other stressful life experiences. Early recognition of PDS is essential to reduce its long-term impact on mothers and their children, but postpartum checkups are highly underutilized. This study examined how stressful life experiences and race-based discrimination influence PDS development and whether or not a women has a postpartum checkup.
View Article and Find Full Text PDFEpigenetics
December 2025
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Perceived discrimination, recognized as a chronic psychosocial stressor, has adverse consequences on health. DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and subsequently affect health outcomes. However, relatively little is known about the effects of perceived discrimination on DNAm.
View Article and Find Full Text PDFEcol Lett
January 2025
Department of Geography, Faculty of Science, Environment and Economy, University of Exeter, Exeter, UK.
Understanding the effects of multiple stressors has become a major focus in ecology and evolution. While many studies have investigated the combined effects of stressors, revealing massive variability, a mechanistic understanding that reconciles the diversity of multiple stressor outcomes is lacking. Here, we show how performance curves can fill this gap by revealing mechanisms that shape multiple stressor outcomes.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
January 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN.
Arterial stiffness is a well-known risk factor for cardiovascular disease. Although estradiol (E2) is known to be cardioprotective, the available data point to a growing cardiovascular disease risk in women before menopause due to post-traumatic stress disorder (PTSD). The present study aimed to investigate the effects of E2 on arterial compliance in trauma-exposed premenopausal women, with and without a clinical diagnosis PTSD.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China; Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei 230601, China. Electronic address:
The emergence of cuproptosis, a novel form of regulated cell death, is induced by an excess of copper ions and has been associated with the progression of multiple diseases, including liver injury, cardiovascular disease, and neurodegenerative disorders. However, there are currently no inhibitors available for targeting specific cuproptosis-related pathways in therapy. Here, the compound merestinib (MTB) has been identified as a strong inhibitor of cuproptosis through screening of a kinase inhibitor library.
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