2-Chloromethyl 3-N-substituted arylthieno (2,3-d)pyrimidin-4-ones and derivatives were synthesized by reacting 2-amino-3-carboxanilido-4,5,6,7-tetrahydrobenzo(b)thiophenes (Iabc) with chloroacetyl chloride in dioxane and by cyclizing the open chain 3-substituted carboxanilido-2-(omega-chloroacetamido)-4,5,6,7-tetrahydrobe nzo(b)thiophenes (IIabc) under acidic condition. The compounds were characterized by their spectral data and screened for central nervous system depressant activity. The compounds IIIabc and Vabc have shown marked sedative action.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
arylthieno 23-dpyrimidin-4-ones
8
23-dpyrimidin-4-ones derivatives
8
central nervous
8
nervous system
8
system depressant
8
depressant activity
8
synthesis evaluation
4
evaluation 2-chloromethyl-3-n-substituted
4
2-chloromethyl-3-n-substituted arylthieno
4
derivatives central
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!