Numerous routes of access to the medial basal structures of the cranium have been described, largely because of the wide variety of lesions observed in deep localizations. Access can be achieve via trans-sinusal, transfacial (trans-sphenoidal rhinoseptal, mediofacial or Lefort I), trans-oro-pharyngeal and numerous other routes. An examination of the principals involved, their development and the technical modalities demonstrate the advantages and disadvantages of each and their specific indications. Access is particularly interesting with the frontal trans-sphenoid, Lefort I osteotomy and trans-oro-pharyngeal routes. The simplicity of these non-mutilating routes provide an alternative to neurosurgical access. Their development depends on progress in imaging and microscopic surgery. Used alone or in combination, they can be an useful complement to a neurosurgical access.
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PLoS One
January 2025
School of Economics & Management, Shanghai Maritime University, Shanghai, China.
Analyzing the interactions between spot and time charter freight is crucial for the maritime industry. While numerous studies have explored the relationship between average freight indices and spillover effects, a gap remains in understanding the deeper connections between inter-regional shipping routes and chartering contracts. This research investigates the role of Capesize freight dynamics in shaping the regional dry bulk freight market, with a focus on the influence of energy and commodity price fluctuations.
View Article and Find Full Text PDFVaccines (Basel)
December 2024
Department of Basic Research, Ab & B Bio-Tech Co., Ltd. JS, Taizhou 225300, China.
Background/objectives: The H7N9 avian influenza virus (AIV) constitutes a novel subtype of influenza virus that has emerged within the past decade. Empirical studies have demonstrated that H7N9 AIV holds the potential to trigger a human pandemic. Vaccines constitute the sole armament available to humanity in combating influenza epidemics.
View Article and Find Full Text PDFEnviron Toxicol
January 2025
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, China.
The wide range of applications and the enormous production of nanomaterials have raised the possibility that humans may simultaneously contact with various nanomaterials through multiple routes. Although numerous toxicity studies have been conducted on the toxicity of nanomaterials, knowledge of the combined toxicity of nanomaterials remains limited. Herein, the combined toxic effects of the two types of the most widely used nanomaterials, silver and silica, were studied on HeLa cells.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Institute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
mRNA vaccines offer groundbreaking technological advantages and broad application potential. Their rapid advancement, particularly during the COVID-19 pandemic, is the result of decades of research and numerous technological breakthroughs. These discoveries build upon each other, forming dense, interconnected networks of progress.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2025
EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Effective decontamination of hospital surfaces is crucial to protect workers from antineoplastic drugs (ADs) since dermal absorption is the main exposure route to these hazardous medicinal products. Sampling after daily cleaning in oncologic settings from a tertiary hospital was initially performed and exhibited low contamination levels; however, cyclophosphamide was still found (up to 957 pg/cm) above the guidance value (100 pg/cm) in four locations, evidencing the need to properly assess and update the cleaning protocols. Then, cleaning efficiencies of six solutions and different protocols were evaluated (including, for the first time, four commercial cleaning solutions/disinfectants not designed specifically for AD removal) after deliberate contamination of three model surfaces with 13 pharmaceuticals: bicalutamide, capecitabine, cyclophosphamide, cyproterone, doxorubicin, etoposide, flutamide, ifosfamide, imatinib, megestrol, mycophenolate mofetil, paclitaxel, and prednisone.
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