Unlabelled: There are very few reports about the feasibility of maternal milk feeding in very low birthweight preterm infants (VLBW), especially in twins. Therefore we conducted a cohort retrospective study to evaluate the feeding patterns of the 226 VLBW discharged from our neonatal intensive care unit from 1987 to 1996. Their gestational age was 30 +/- 2.6 weeks, birthweight 1166 +/- 224 g and they were hospitalized for 67 +/- 37 days (means +/- 1 SD). Of the 226 VLBW 49% were males, 39% had birthweight below 10 degrees centile for gestational age and 56% were born to non-residents in our area. There were 181 single births and 45 (20%) multiple births, of which 16 from pregnancies with 3 or more fetuses. Of the total cases 22% were discharged feeding maternal milk (MM) exclusively and 21% on mixed-feeding, maternal + formula milk (FM). Percentages were respectively 23% and 18% for single newborns, 11% and 29% for twins. Singletons and twins were discharged on FM with comparable percentages (59 and 60%). With passing years we have noticed a significant increase (chi square for linear trend < 0.01) for maternal milk feeding. In the last 2 years 49% of singletons and 38% of twins were discharged on MM, 14% and 24% on MM + FM, and only 37% and 38% on FM only. Between singletons and twins there were no statistically significant differences as far as feeding at discharge is concerned.
Conclusions: most mothers, if correctly informed and encouraged, are able to breast-feed, exclusively or partially, their VLBW offspring, including twins, in the first months of life.
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Anim Biotechnol
December 2025
Department of Plant, Soil and Food science, University of Bari, Aldomoro, Italy.
Variation in litter size (LS) in sheep is linked to genetic factors, including the Zona pellucida-3 (ZP3) gene, which plays a role in ovine reproductive processes. This study examined the association between ZP3 gene variations and LS in Kari sheep. Two groups of 160 Kari ewes were analysed: one consistently producing singletons and another producing twins, with occasional triplets.
View Article and Find Full Text PDFEnviron Int
January 2025
Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address:
There is growing concern that exposure to per/polyfluoroalkyl substances (PFAS), persistent chemicals used widely to make consumer products water- or grease-proof, may alter immune function, leading to reduced vaccine response or greater susceptibility to infections. We investigated associations between two legacy PFAS (PFOA and PFOS) and infant cytokine levels measured in newborn dried bloodspots (NDBS) from a large population-based birth cohort in Upstate New York, to determine whether exposure to legacy PFAS is associated with variability in cytokine profiles in newborns. We performed adjusted mixed effects regressions for each cytokine against PFOS and PFOA followed by exploratory factor analysis (EFA) on specific cytokine subsets selected via the prior regressions.
View Article and Find Full Text PDFEvol Med Public Health
January 2025
Department of Health, Society, and Behavior, Joe C. Wen School of Population and Public Health, University of California, Irvine, CA, USA.
Background And Objectives: Research to identify fetal predictors of infant mortality among singletons born in the United States (US) concludes that poorly understood and unmeasured "confounders" produce a spurious association between fetal size and infant death. We argue that these confounders include Vanishing Twin Syndrome (VTS)-the clinical manifestation of selection against frail male twins . We test our argument in 276 monthly conception cohorts conceived in the US from January 1995 through December 2017.
View Article and Find Full Text PDFTransl Pediatr
December 2024
Department of Medical Genetics Centre, Guangdong Women and Children Hospital, Guangzhou, China.
Background: Intrauterine growth restriction (IUGR) which is judged based on birth weight and gestational age, is associated with increased neonatal mobility and mortality and also has a further impact on physical and mental health during later in life. Using the birth weight percentile for singletons to assess twins might not accurately reflect the growth status of the twins; this could potentially lead to an incorrect evaluation of growth-restricted children. For a more precise assessment of twin newborns, it is beneficial to utilize twin-specific birth weight percentile curves and ponderal index (PI) curves that consider factors such as birth order and sex.
View Article and Find Full Text PDFObstet Gynecol
January 2025
Riley Children's, the Division of Maternal-Fetal Medicine, Indiana University Health Fetal Center, and the Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana; the Division of Maternal-Fetal Medicine and Surgery, Fetal Care and Surgery Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; the Department of Obstetrics and Gynecology, Brown University Medical School, Providence, Rhode Island; the Fetal Medicine Unit, St George's Hospital, St George's University of London, London, United Kingdom; the Division of Maternal-Fetal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania; and the Division of Maternal-Fetal Medicine, The Ohio State University, Columbus, Ohio.
Objective: To investigate short-term maternal and neonatal outcomes in individuals with twin pregnancies and two prior cesarean deliveries who underwent trial of labor after cesarean (TOLAC).
Methods: A cross-sectional study of live-birth data was conducted between 2014 and 2021 in the United States. Individuals with more than two prior cesarean deliveries and multiple gestations higher than twins were excluded.
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