Background And Methods: Alcohol is the leading cause of acute poisoning in Trieste teenagers and one of the main public health problems in general population. Planning of effective prevention is limited by lack of information on alcohol drinking habits and notions of young people.
Materials And Methods: A questionnaire study has been carried out on 769 school teen-agers in Trieste and Gorizia provinces. The anonymous questionnaire concerned alcohol use and daily consumption, age and site of first approach, favourite beverages, number of acute abuse during the last year, awareness of the problem and opinion on social aspects.
Results: Near half of school teen-agers reported alcohol drinking. First approach occurred more frequently at home, because of curiosity or parents emulation and it was especially precocious for wine and beer (mode 8-10 yrs) respect to spirits (mode 12 yrs). In males and in both gender with increasing age higher rates of drinkers, alcohol consumption and acute poisoning were reported. More than 8 of 10 children judged the alcohol to be not a food but a drug, whose consumption is not necessary to affirm the personality. However, for more that 8 of 10 subjects alcohol warms, for about half of them it is stimulant. Only 4 of 10 were aware that its sale is forbidden by law under 16 years of age.
Conclusions: Due to early initiation, family responsibility and lack of awareness of the problem, a correct alcohologic information to families and teen-agers is needed. Pediatricians can and must have a main role at this regard, but their action must be associated with reduction of our society tolerance on alcohol drinking.
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Am J Pathol
January 2025
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA; Department of Internal Medicine, Division of Gastroenterology, Hepatology & Mobility, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. Electronic address:
Alcohol-associated liver disease (ALD) is a significant global health concern and a leading cause of liver disease-related deaths. However, the treatment options are limited due to the lack of animal models that accurately replicate ALD pathogenesis. An ideal ALD animal model should have pathological characteristics similar to those of human ALD, with a clear pathological process and ease of drug intervention.
View Article and Find Full Text PDFMult Scler Relat Disord
January 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address:
Background: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. However, the association of IGF-1 with the risk of multiple sclerosis (MS) remains unclear.
Methods: A total of 348,324 participants at baseline were included from the UK biobank in this prospective study.
Risk Manag Healthc Policy
January 2025
Université Paris Cité, Inserm U1266, Institut de Psychiatrie et Neurosciences de Paris (IPNP), Team Vulnerability of Psychiatric and Addictive Disorders, Paris, France.
Purpose: Alcohol use is a leading risk factor for preventable death, injury, and disease globally. Low sensitivity to the effects of alcohol is influenced by genes and predicts risk for harmful alcohol use and alcohol use disorder (AUD). Alcohol induces effects partly by modulation of gamma-aminobutyric acid receptors type A (GABARs).
View Article and Find Full Text PDFRev Med Suisse
January 2025
Service de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.
This article presents the latest recommendations for the promotion of health and prevention. This article is primarily addressed to public health actors and stakeholders. The recommendations are contextualized to the local reality, based on Geneva-specific data from the longitudinal Specchio studywhich evaluates the health status of the Geneva population and its determinants.
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