Sry, the mammalian Y-linked testis determining gene, is a member of a family of genes known as Sox genes, which encode transcription factors related by a DNA-binding motif termed the HMG box. Sox genes are known to have diverse roles in vertebrate differentiation and development. We report here the cloning and characterisation of one of these genes, Sox11, in mice. In addition to an N-terminal HMG box domain, the deduced SOX11 protein contains a number of highly conserved C-terminal motifs, which may function in transcriptional regulation. Expression of Sox11 in mouse embryos was prominent in the periventricular cells of the central nervous system, suggesting a role in neuronal maturation. Expression was also observed in a wide range of tissues involved in epithelial-mesenchymal interactions, suggesting an additional role in tissue modelling during development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/(SICI)1097-0177(199710)210:2<79::AID-AJA1>3.0.CO;2-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Specification of claustro-amygdalar and palaeocortical neurons and circuits.
Nature
January 2025
Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
The ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that results in adaptive behaviours. Early-life disruptions in these circuits are linked to neuropsychiatric disorders, highlighting the importance of understanding their development. Here we reveal that the transcription factors SOX4, SOX11 and TFAP2D have a pivotal role in the development, identity and PFC connectivity of these excitatory neurons.
View Article and Find Full Text PDFSOX11 silence inhibits atherosclerosis progression in ApoE-deficient mice by alleviating endothelial dysfunction.
Exp Cell Res
January 2025
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, 050017, Hebei, China; Department of Cardiology, Hebei General Hospital, Shijiazhuang, 050051, Hebei, China. Electronic address:
SRY-Box Transcription Factor-11 (SOX11) is a transcriptional regulatory factor that plays a crucial role in inflammatory responses. However, its involvement in atherosclerosis (AS), a cardiovascular disease driven by endothelial cell inflammation, remains unknown. This study aims to elucidate the role of SOX11 in AS.
View Article and Find Full Text PDFGenomic Landscape of Superficial Malignant Peripheral Nerve Sheath Tumor.
Lab Invest
November 2024
Department of Pathology, Cleveland Clinic Pathology and Laboratory Medicine Institute, Cleveland, Ohio; Center for Immunotherapy and Precision Immuno-Oncology and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:
Article Synopsis
- Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers that share some features with spindle cell melanomas and desmoplastic melanomas, but their biological characteristics remain poorly understood.* -
- A study comparing SF-MPNST to other tumor types through whole-exome and RNA sequencing found that SF-MPNST had an intermediate tumor mutational burden and distinct gene expression patterns, indicating differences among these cancer types.* -
- Immunohistochemical analysis revealed notable differences in markers like H3K27me3 and PRAME between SF-MPNST and other cancers, suggesting potential for new diagnostic markers and insights into tumor behavior.*
Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based Approach.
Biomedicines
October 2024
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London SE1 9RT, UK.
: Despite current treatments extending the lifespan of Glioblastoma (GBM) patients, the average survival time is around 15-18 months, underscoring the fatality of GBM. This study aims to investigate the impact of sample heterogeneity on gene expression in GBM, identify key metabolic pathways and gene modules, and explore potential therapeutic targets. : In this study, we analysed GBM transcriptome data derived from The Cancer Genome Atlas (TCGA) using genome-scale metabolic models (GEMs) and co-expression networks.
View Article and Find Full Text PDFGenome-Wide Association Studies (GWAS) and Transcriptome Analysis Reveal Male Heterogametic Sex-Determining Regions and Candidate Genes in Northern Snakeheads ().
Int J Mol Sci
October 2024
Key Laboratory of Tropical and Subtropical Fishery Resources Application and Cultivation, Ministry of Agriculture and Rural Affairs, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China.
Article Synopsis
- - The Northern snakehead is an important aquaculture species in China, and research shows distinct growth differences based on sex, making mono-sex breeding highly beneficial for farming.
- - Through genome-wide association studies (GWAS) and transcriptome analysis, researchers identified 270 sexually dimorphic genetic markers and created two specific markers that can determine genetic sex in these fish.
- - A key sex-determination region was found on chromosome 3, along with three candidate genes linked to sex determination, suggesting the existence of a male heterogametic XX/XY system in Northern snakeheads.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!