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The Effect of Prolonged Antenatal Intravenous Immunoglobulin Treatment in Preventing Gestational Alloimmune Liver Disease-A Case Series with Literature Review.
AJP Rep
January 2025
Department of Pediatric Hematology-Oncology, Cooper Medical School of Rowan University, Camden, New Jersey.
Gestational alloimmune liver disease (GALD) is characterized by maternal IgG-directed fetal hepatocyte damage and can lead to severe liver failure and fetal or infant death. Moreover, GALD is associated with a near 90% risk of recurrence in subsequent pregnancies. We present a case of a newborn patient delivered to a 32-year-old G2P1000 mother who received prolonged antenatal intravenous immunoglobulin (IVIG) treatment during the current pregnancy due to the neonatal death of the first child from GALD-related liver failure.
View Article and Find Full Text PDFNeonatal Liver Imaging: Techniques, Role of Imaging, and Indications.
Radiographics
December 2024
From the Department of Diagnostic and Interventional Radiology (F.H., C.R., G.B.C.), Department of Pediatric Laboratory Medicine, Division of Pathology (I.S.), and Division of Neonatology (C.T.), The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8; and Departments of Medical Imaging (F.H., C.R., G.B.C.), Laboratory Medicine and Pathobiology (I.S.), and Pediatrics (C.T.), University of Toronto, Toronto, Ontario, Canada.
The neonatal liver may be affected by a variety of congenital and acquired diseases. Imaging has an important role in the workup and management of many neonatal hepatic abnormalities. Some aspects of imaging the liver and imaging findings are specific to neonatal patients when compared with those in older children.
View Article and Find Full Text PDFA Rare Afferent Loop Syndrome Case in Adulthood Following Liver Transplantation in Neonatal Hemochromatosis.
Gastro Hep Adv
December 2023
Department of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan.
Afferent loop syndrome, sometimes referred to as afferent limb syndrome, is an infrequent mechanical complication frequently observed following foregut surgeries involving the connection of the stomach or esophagus to the jejunum. This condition is commonly found in individuals who have undergone Billroth II reconstruction following a partial gastrectomy. Here, we present the first documented case of afferent loop syndrome in a patient with a medical history involving a liver transplant due to neonatal hemochromatosis.
View Article and Find Full Text PDFSuccessful living-donor liver transplantation for neonatal hemochromatosis due to transient abnormal myelopoiesis with Down syndrome: Case report and review of the literature.
Pediatr Blood Cancer
October 2024
Department of Pediatrics, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.
Unique presentation of neonatal liver failure: A case report.
World J Clin Pediatr
June 2024
Department of Pediatrics, Division of Pediatric Gastroenterology, Sheikh Khalifa Medical City, Abu Dhabi 971, United Arab Emirates.
Background: Acute fulminant liver failure rarely occurs in the neonatal period. The etiologies include viral infection (15%), metabolic/genetic disease (10%), hematologic disorders (15%), and ischemic injury (5%). Gestational alloimmune liver disease usually manifests as severe neonatal liver failure, with extensive hepatic and extrahepatic iron overload, sparing the reticuloendothelial system.
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