AI Article Synopsis
- This study used a paired stimulus approach to examine the P1 auditory evoked potential in Vietnam War veterans with PTSD and compared them to three other groups: alcohol dependents, combat-exposed normals, and combat-unexposed normals.
- The results showed that veterans with PTSD had significantly less habituation of the P1 potential compared to the other groups, indicating a possible sensory gating issue in their brainstem.
- Additionally, the level of P1 potential habituation in the PTSD group was significantly linked to the severity of their PTSD reexperiencing symptoms, like nightmares and flashbacks.
Article Abstract
The current study used a paired stimulus paradigm to investigate the P1 midlatency auditory evoked potential in Vietnam combat veterans with posttraumatic stress disorder (PTSD) and three comparison groups: alcohol dependents, combat-exposed normals, and combat-unexposed normals. Compared to each comparison group, PTSD subjects exhibited significantly diminished habituation of the P1 potential. P1 potential habituation within the PTSD group, correlated significantly with intensity of PTSD reexperiencing symptoms, such as trauma-related nightmares and flashbacks. These findings are discussed as consistent with a sensory gating defect at the brainstem level in PTSD, and are further discussed in the context of other psychophysiological measures in PTSD and of P1 potential findings in psychiatric disorders other than PTSD.
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| http://dx.doi.org/10.1016/s0024-3205(97)00688-7 | DOI Listing |
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