Genetic transmission in manic depressive disorder (MDD) has been explored in linkage and association studies. The X-linked transmission hypothesis has been tested by using several markers on chromosome X. The hypothesis of autosomal transmission has been tested by association studies with the 0 blood group located on chromosome 9, as well as linkage studies on chromosome 6 and chromosome 11. Although linkage studies support the hypothesis of a major locus, several factors are limiting the results which are discussed in the present review.
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