AI Article Synopsis
- The study examined the CD8+ cytotoxic T lymphocyte response to a specific Epstein-Barr virus (EBV) peptide in five healthy HLA-B8-positive virus carriers, with four infected with type A and one with type B EBV.
- Using limiting-dilution analysis, researchers found a high frequency of CTL precursors specific to the peptide RAKFKQLLQ in all carriers after stimulation, indicating strong immune response.
- The dominant CTL precursor frequencies for RAKFKQLLQ were comparable to those for two other EBV-related epitopes, suggesting that healthy carriers maintain robust memory T cell populations to help control potential virus spread.
Article Abstract
Five healthy human leukocyte antigen-B8 (HLA-B8)-positive virus carriers were studied to investigate the CD8+ cytotoxic T lymphocyte (CTL) response to an HLA-B8-restricted peptide, RAKFKQLLQ, located in the Epstein-Barr virus (EBV) immediate-early trans-activator protein, BZLF1. Of the 5 virus carriers, 4 were infected with type A and 1 with type B EBV. Using limiting-dilution analysis of peripheral blood mononuclear cells, a high RAKFKQLLQ-specific CTL precursor frequency was demonstrated after specific peptide or autologous lymphoblastoid cell line stimulation in both type A and type B EBV carriers. The RAKFKQLLQ-specific CTL precursor frequencies in all 5 persons were at least as dominant as those observed with two other EBV-associated, HLA-B8-restricted latent epitopes, FLRGRAYGL and QAKWRLQTL. These findings show that healthy virus carriers maintain a high frequency of BZLF1-specific memory T cells, potentially to control virus spread from lytically infected cells.
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| http://dx.doi.org/10.1086/516513 | DOI Listing |
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