Purpose: To evaluate the usefulness of transcutaneous needle biopsy (TCNB).
Material And Methods: From May 1988 to December 1994, we performed TCNB under fluoroscopic control in 408 patients with mass lesions of the peripheral lung. The Surecut needle (1.5 mm) was selected mainly because of its ability to obtain specimens large enough for histological examination. Of the 408 patients, 286 had had previous bronchofiberscopic examinations but no definite diagnosis had been reached.
Results: A definite diagnosis was obtained by TCNB in 305 (74.7%) of 408 cases (251 malignant neoplasms, 54 benign lesions). In malignant neoplasms, the pathological diagnosis based on cytology and histology together was more reliable than that based on cytology alone. Although the complications of this procedure (such as pneumothorax) were within the range of acceptability, care should be taken to avoid air embolism and the seeding of cancer cells along the needle tract.
Conclusion: TCNB with the Surecut needle is a useful procedure with relatively low risk.
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http://dx.doi.org/10.1080/02841859709172417 | DOI Listing |
ACS Mater Au
January 2025
Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore 560012, India.
The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged as a prominent area of focus in biomedical research because of its ability to deliver a wide range of biomolecules, vaccines, medicines, and other substances through the skin. Microneedles (MNs) form microchannels by disrupting the skin's structure, which compromises its barrier function, and facilitating the easy penetration of drugs into the skin.
View Article and Find Full Text PDFClin Exp Allergy
January 2025
Service de Pneumologie A, APHP, Hôpital Bichat, Paris, France.
Adrenaline is the first line treatment for anaphylaxis and adrenaline auto-injectors (AAI) allow reliable, safe and ergonomic administration in the community. However, AAIs have significant limitations and adrenaline is often not used in anaphylaxis. Innovations to administer adrenaline via alternative routes may potentially improve usage rates and treatment effectiveness.
View Article and Find Full Text PDFAcupunct Med
December 2024
Department of Physiotherapy, University of Seville, Seville, Spain.
Background: Electrical nerve stimulation is an effective therapeutic tool in the field of rehabilitation for the management of musculoskeletal conditions.
Objective: To analyze the muscle activity of the short head of the biceps femoris (SHBF) and long head of the biceps femoris (LHBF) after the application of percutaneous electrical nerve stimulation to the common fibular versus tibial nerve compartment of the sciatic nerve.
Methods: Thirty-eight healthy subjects received electrical stimulation (asymmetric biphasic rectangular waveforms) through a needle in the sciatic nerve.
Clin Breast Cancer
February 2025
Anesthesiology and Critical Care Interest Group, Universidad El Bosque Colombian School of Medicine, Bogotá, Colombia. Electronic address:
Objective: Literature regarding nonpharmacological interventions (NPI) for PMPS or CP after mastectomy is scarce and not fully appraised, therefore we conducted this systematic review to explore the current panorama of treatment options.
Methods: A systematic review to assess the existing evidence regarding nonpharmacological approaches for PMPS. We reviewed the following databases: PubMed-MEDLINE, Embase, and Ovid (including the Cochrane Database for Clinical studies) using the following search terms: CP, mastectomy, and PMPS, and adjusted the terms depending on the database used.
Therap Adv Gastroenterol
November 2024
Stravitz-Sanyal Institute of Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, 1201 E. Broad St. P.O. Box 980341, Richmond, VA 23284, USA.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern worldwide. Liver biopsy is the gold standard for diagnosing and staging MASLD, but it is invasive and carries associated risks. In recent years, there has been significant progress in developing noninvasive techniques for evaluation.
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