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Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets.
Circulation
February 2015
From the Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-J.J., J.-S.C.); Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.Y., J.-S.C.); Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (R.-B.H.); Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (C.-M.L.); and Department of Forensic Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (C.-T.S.).
Background: Endocarditis-inducing streptococci form multilayered biofilms in complex with aggregated platelets on injured heart valves, but the host factors that interconnect and entrap these bacteria-platelet aggregates to promote vegetation formation were unclear.
Methods And Results: In a Streptococcus mutans endocarditis rat model, we identified layers of neutrophil extracellular traps interconnecting and entrapping bacteria-platelet aggregates inside vegetation that could be reduced significantly in size along with diminished colonizing bacteria by prophylaxis with intravascular DNase I alone. The combination of activated platelets and specific immunoglobulin G-adsorbed bacteria are required to induce the formation of neutrophil extracellular traps through multiple activation pathways.
Candida parapsilosis bioprosthetic valve endocarditis inducing aortic valve stenosis.
Tex Heart Inst J
May 2014
Department of Internal Medicine (Dr. Lee) and Department of Thoracic and Cardiovascular Surgery (Drs. Choi and Kim), Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju 561-712, Republic of Korea.
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View Article and Find Full Text PDFPlatelets enhance biofilm formation and resistance of endocarditis-inducing streptococci on the injured heart valve.
J Infect Dis
April 2012
Graduate Institute of Microbiology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Infective endocarditis is a typical biofilm-associated infectious disease frequently caused by commensal streptococci, but the contribution of host factors in biofilm formation is unclear. We found that platelets are essential for in vitro biofilm formation by Streptococcus mutans or Streptococcus gordonii grown in human plasma. The biofilms were composed of bacterial floes embedded with platelet aggregates in layers, and a similar architecture was also detected in situ on the injured valves of a rat model of experimental endocarditis.
View Article and Find Full Text PDFPacemaker-related endocarditis inducing tricuspid stenosis.
Am Heart J
May 1997
Department of Cardiology, Erasme Hospital, Brussels, Belgium.
Infective endocarditis-inducing abilities of "Streptococcus milleri" group.
Adv Exp Med Biol
December 1997
Department of Preventive Dentistry, Kagoshima University Dental School, Japan.
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