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Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling.
J Transl Med
January 2025
Aerospace Medical Center, Aerospace Center Hospital, Beijing, China.
Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy.
View Article and Find Full Text PDFDirect Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis.
J Org Chem
January 2025
Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
The direct cross-couplings of aryl nonaflates with aryl bromides could be successfully accomplished by utilizing nickel as the catalyst, magnesium as the metal mediator, and lithium chloride as the additive. The reactions proceeded efficiently in THF at room temperature to produce the desired biaryls in moderate to good yields, showing both a reasonable substrate scope and functional group tolerance. Additionally, an equally good performance could be realized when the reaction was subjected to scale-up synthesis.
View Article and Find Full Text PDFThe Posterior Ligamentous Complex: Anatomic and Biomechanical Considerations in Injury Classification and Management.
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedics (A. Mo and F. Mo), Medstar Georgetown University Hospital, Washington, DC, and the Department of Orthopaedic Surgery (S. Lockey), University of Virginia, Charlottesville, VA.
The posterior ligamentous complex (PLC) provides critical structural support in the thoracolumbar spine. Its role in resisting progressive flexion is particularly important at the thoracolumbar junction due to the transition from the rigid thoracic spine to the more mobile lumbar region. Each component of the PLC contains anatomic features that contribute to both the structure and function of the PLC as a whole.
View Article and Find Full Text PDFExploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.
Alzheimers Dement
January 2025
Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York, USA.
This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia-T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau.
View Article and Find Full Text PDFAnatomical limits of the parapharyngeal space using a transoral endoscopic approach - Radioanatomical study in cadaver.
Eur Arch Otorhinolaryngol
January 2025
Otorhinolaryngology Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Purpose: The aim of this study is to obtain the anatomical limits of the parapharyngeal space by transoral surgical approach, in order to objectively determine the types of lesions according to location, where this type of approach is more indicated.
Methods: A prospective, experimental, radio-anatomical study was performed on 10 cryopreserved human heads(20 sides). A transoral approach of the parapharyngeal space was performed determining its anatomical limits by CT navigation.
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