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Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations , , and .
Front Physiol
December 2024
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Introduction: Adrenergic activation of protein kinase A (PKA) in cardiac muscle targets the sarcolemma, sarcoplasmic reticulum, and contractile apparatus to increase contractile force and heart rate. In the thin filaments of the contractile apparatus, cardiac troponin I (cTnI) Ser22 and Ser23 in the cardiac-specific N-terminal peptide (NcTnI: residues 1 to 32) are the targets for PKA phosphorylation. Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca associated with a higher rate of Ca dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy).
View Article and Find Full Text PDFSingle-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta.
Placenta
December 2024
Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel. Electronic address:
Introduction: Single-cell RNA-seq (scRNA-seq) revolutionized our understanding of tissue complexity in health and disease and revealed massive transcriptional dysregulation across placental cell classes in early-onset, but not late-onset preeclampsia (PE). However, the multinucleated syncytium is largely inaccessible to cell dissociation. Nuclei isolation and single-nuclei RNA-seq may be preferable in the placenta; not least considering compatibility with long-term tissue storage.
View Article and Find Full Text PDFSingle-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation.
Sci Rep
December 2024
Department of Critical Care Medicine, Heping Hospital Affiliated to Changzhi Medical College, 110 South Yan'an Road, Luzhou District, Changzhi City, 046012, China.
Mechanical ventilation contributes to diaphragm atrophy and muscle weakness, which is referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The pathogenesis of VIDD has not been fully understood until recently. The aim of this study was to investigate the effects of 24 h of mechanical ventilation on fibro-adipogenic progenitor (FAP) proliferation, endothelial-mesenchymal transition (EndMT), and immune cell infiltration driving diaphragm fibrosis in a rabbit model.
View Article and Find Full Text PDFHuman enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease.
Gastroenterology
December 2024
Department of Clinical Genetics, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Pediatric Surgery, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address:
Background And Aims: The enteric nervous system (ENS), comprised of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation, yet while neuronal aspects have been extensively studied, enteric glia remain disregarded. This study aimed to explore enteric glia diversity in health and disease.
View Article and Find Full Text PDF[Evolution of views on the phenomenon of spiritual possession within the framework of psychiatric pathology (psychopathological, transnosological and transcultural aspects)].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Mental Health Research Center, Moscow, Russia.
The spiritual possession phenomenon (SPP), is a complex transnosological, transcultural syndrome, which is based on the patients' perception that some spiritual entity (spirit, demon, jinn, shaitan, «ikotka», dybbuk, Buddha, etc.) is influencing or possessing them. Modern classifications of diseases, aimed at expanding our ideas about the distinction between the norm and pathology of mental disorders, do not contribute to a clear psychopathological differentiation of SPP, the determination of its nosological affiliation and the choice of appropriate therapeutic tactics for these conditions.
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