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Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects.
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Institute of Food Science Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan, R.O.C.
This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol.
View Article and Find Full Text PDFBee pollen peptides as potent tyrosinase inhibitors with anti-melanogenesis effects in murine b16f10 melanoma cells and zebrafish embryos.
Sci Rep
December 2024
Center of Excellence in Bioconversion and Bioseparation for Platform Chemical Production, Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand.
One important functional food ingredient today, valued for its health properties and ability to prevent disease, is bee pollen, which comprises a combination of nectar, pollen from plants, and the secretions of bees. In this research, the tyrosinase (TYR) inhibiting abilities of the peptides derived from bee pollen protein hydrolysates are investigated. Various proteases were utilized to generate these peptides, followed by testing at different concentrations.
View Article and Find Full Text PDFFunctional analysis of dopa decarboxylase in the larval pupation and immunity of the diamondback moth, Plutella xylostella.
Pestic Biochem Physiol
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Collaborative Innovation Center for Modern Grain Circulation and Safety, College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210023, China. Electronic address:
The diamondback moth (Plutella xylostella L.), a notorious pest infesting cruciferous vegetables worldwide, has developed a high level of resistance to various commonly used chemical pesticides. In this paper, we explore whether dopa decarboxylase (DDC), which is essential for survival and development in insects, could be used as a potential target for the control of P.
View Article and Find Full Text PDFA Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries.
Molecules
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Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultra-high-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms.
View Article and Find Full Text PDFNovel deoxyhypusine synthase (DHPS) inhibitors target hypusination-induced vasculogenic mimicry (VM) against malignant melanoma.
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November 2024
Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:
Article Synopsis
- This study focuses on developing inhibitors for deoxyhypusine synthase (DHPS), which is crucial for targeting vasculogenic mimicry (VM) in malignant melanoma, a factor linked to poor patient outcomes.
- A new compound, 7k, was identified as effective in inhibiting DHPS activity and was shown to affect the expression of specific genes involved in VM, contributing to its anti-melanoma properties.
- Testing in zebrafish and various models shows that 7k not only impacts melanoma cell behavior but also demonstrates significant effectiveness against melanoma growth, revealing DHPS as a vital target for treatment.
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