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Hospitalizations for Respiratory Syncytial Virus and Vaccine Preventable Infections following Pediatric Heart Transplantation.
J Pediatr
September 2021
The Heart Center, Nationwide Children's Hospital, Columbus, OH.
Objective: To determine the risk factors for acquiring a respiratory syncytial virus (RSV) and vaccine-preventable infections (R/VPI) in pediatric heart transplant recipients and the associated morbidity and hospital resource use.
Study Design: Patients <18 years who underwent heart transplantation from September 2003 to December 2018 at hospitals using the Pediatric Health Information System database were identified. Their transplant hospitalization and subsequent hospitalizations for R/VPI through December 2018 were analyzed.
Patterns and correlates of preserved humoral immunity to vaccines in children following allogeneic hematopoietic stem cell transplantation.
Pediatr Transplant
August 2021
Children's Hospital of Michigan, Division of Hematology/Oncology, Pediatric Bone Marrow Transplantation Program, Detroit, MI, USA.
Data on preservation of vaccine immunity following allogeneic HSCT in children is limited. We investigated vaccine titers and sought correlations with patient characteristics in this study. Twenty-eight cases were retrospectively analyzed.
View Article and Find Full Text PDFPatient education and recall regarding postsplenectomy immunizations.
J Surg Res
December 2015
Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Background: The purpose of this study was to determine the rates of initial vaccinations after splenectomy for trauma, assess the effectiveness of patient education on reimmunizations, and evaluate patients' utilization of their knowledge regarding immunization after discharge.
Methods: From June 1996-December 2011, 144 patients underwent splenectomy after traumatic injury. A telephone survey was completed in 100 of 144 splenectomized patients (69%) at a mean of 7.
Status of immunity for vaccine--preventable diseases in children after hematopoietic stem cells transplantation.
Przegl Epidemiol
July 2012
Department of Clinical Immunology and Transplantatology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow.
Introduction: patients treated with hematopoietic stem cell transplantation (HSCT) lose immune memory accumulated through a lifetime. They are at increased risk of developing infections with microorganisms such as Haemophilus influenza, Streptococcus pneumoniae and others for which vaccines are available. Therefore, all patients after HSCT should be routinely revaccinated.
View Article and Find Full Text PDFA peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.
Infect Immun
January 2005
Albert Einstein College of Medicine, Division of Infectious Diseases, Room 709 Forchheimer Bldg., 1300 Morris Park Ave., Bronx, NY 10461, USA.
Increasing antibiotic resistance and a rising patient population at risk for infection due to impaired immunity underscore the importance of vaccination against pneumococci. However, available capsular polysaccharide vaccines are often poorly immunogenic in patients at risk for pneumococcal disease. The goal of this study was to explore the potential of peptide mimotopes to function as alternative vaccine antigens to elicit a type-specific antibody response to pneumococci.
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