AI Article Synopsis
- A new gas-liquid chromatography (GLC) method was created to measure thioridazine, mesoridazine, and their metabolites along with other phenothiazines.
- Seven phenothiazine derivatives, including thioridazine and six of its known metabolites, were successfully extracted and separated using this method.
- The method's effectiveness was evaluated by analyzing plasma samples from 30 psychiatric patients being treated with thioridazine or mesoridazine.
Article Abstract
A GLC method for measuring thioridazine, mesoridazine, their metabolites, and possibly other phenothiazines was developed. By using this method, seven different phenothiazine derivatives, thioridazine, and six known thioridazine metabolites were extracted and separated. This method was tested by assaying plasma samples from 30 hospitalized psychiatric patients receiving thioridazine or mesoridazine.
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| http://dx.doi.org/10.1002/jps.2600650509 | DOI Listing |
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