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Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis.
Antioxidants (Basel)
July 2024
Department of Medicine, Division of Gastroenterology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, Tochigi, Japan.
The role of ferroptosis in steatohepatitis development is largely unknown. We investigated (1) whether hepatocyte ferroptosis occurs in a gene-modified steatohepatitis model without modifying dietary components, (2) whether ferroptosis occurs at an early stage of steatohepatitis, and (3) whether apomorphine, recently reported as a ferroptosis inhibitor, can ameliorate steatohepatitis. Hepatocyte-specific PTEN KO mice were used.
View Article and Find Full Text PDFDSP-6745, a novel 5-hydroxytryptamine modulator with rapid antidepressant, anxiolytic, antipsychotic and procognitive effects.
Psychopharmacology (Berl)
November 2024
Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, 554-0022, Japan.
Article Synopsis
- Current treatments for major depressive disorder struggle with low success rates and complications from symptoms like psychosis, while serotonin neurotransmission is an important focus for new drug targets.
- This study investigates DSP-6745, a new serotonin modulator, and its effects on depression and related symptoms.
- Results show that DSP-6745 acts as a potent serotonin transporter inhibitor and enhances neurotransmitter release, leading to rapid antidepressant-like effects and improvements in anxiety and cognitive function in animal tests.*
Kinetic Properties and Pharmacological Modulation of High- and Low-Affinity Dopamine Transport in Striatal Astrocytes of Adult Rats.
Int J Mol Sci
May 2024
Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Astrocytes actively participate in neurotransmitter homeostasis by bidirectional communication with neuronal cells, a concept named the tripartite synapse, yet their role in dopamine (DA) homeostasis remains understudied. In the present study, we investigated the kinetic and molecular mechanisms of DA transport in cultured striatal astrocytes of adult rats. Kinetic uptake experiments were performed using radiolabeled [H]-DA, whereas mRNA expression of the dopamine, norepinephrine, organic cation and plasma membrane monoamine transporters (DAT, NET, OCTs and PMAT) and DA receptors D1 and D2 was determined by qPCR.
View Article and Find Full Text PDFSynthetic aporphine alkaloids are potential therapeutics for Leigh syndrome.
Sci Rep
May 2024
Department of Pediatrics, Division of Pediatrics, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Mitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or phenotypes. There are only a few approved treatments, and fundamental therapies are yet to be developed. Leigh syndrome (LS) is the most severe type of progressive encephalopathy.
View Article and Find Full Text PDFIntegrating technology into a successful apomorphine delivery program in Thailand: a 10-year journey of achievements with a five-motto concept.
Front Neurol
April 2024
Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Introduction: Apomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson's disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices and specialized care as well as resource consumption, posing challenges for new physicians. Thailand is a unique example of a developing nation that has successfully implemented and continued the use of this therapy by employing cooperative technology that has dramatically enhanced apomorphine delivery services.
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