Stereotactic methodology developed at Sainte-Anne Hospital Center from 1947 is based on the application of a simple spatial geometry-the Talairach Ac-Pc reference system-to the cranial volume and the identification of any anatomical structure or brain lesion within this volume. Now upgraded with modern imaging techniques, this methodology is the ground for multiple applications in functional as well as lesional neurosurgery and is now a a part of the daily neurosurgical practice at Sainte-Anne Hospital. Stereotactic procedures include three steps: first, the identification of one or several target-volumes through stereotactic imaging acquisition: CT, MRI and conventional stereoscopic angiography; second, the image treatment on a dedicated workstation for stereotactic coordinates determination and surgical planning; third, the surgical procedure itself and its control. The most frequent applications for stereotactic methodology are: image-guided stereotactic biopsies of brain tumors, in order to obtain tissue pathological diagnosis and spatial configuration; linac-based radiosurgery of arterio-venous malformations and tumors with high energy collimated beams converging towards a simple or complex target volume; surgery for partial drug-resistant epilepsy including depth electrode implantation for stereo-electroencephalography and epileptogenic cortex resection; stereotactic image-guided resection of superficial or deep-seated tumors or vascular malformation; Rhenium 186 intracavitary irradiation of cystic tumors such as craniopharyngiomas.
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J Neurooncol
January 2025
University of Virginia, Charlottesville, VA, USA.
Background: Even a gross total resection of a benign epidermoid tumor (ET) carries a high risk of recurrence. The management strategy mostly involves redo surgical excision but at a significant cost of morbidity and mortality. The role of adjuvant radiation therapies in this scenario is still undefined.
View Article and Find Full Text PDFJ Appl Clin Med Phys
January 2025
Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, Illinois, USA.
Background: Various methods exist to correct for intrafraction motion (IFM) of the prostate during radiotherapy. We sought to characterize setup corrections in our practice informed by the TrueBeam Advanced imaging package, and analyze factors associated with IFM.
Methods: 132 men received radiation therapy for prostate cancer with a volumetric modulated arc therapy technique.
J Clin Neurosci
January 2025
Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Background: Tremor, either in patients with Essential Tremor (ET) or Parkinson's disease (PD), constitutes the most common movement disorder. Stereotactic radiosurgery using Gamma Knife (GK) and linear accelerator (LINAC) systems, is an effective, incisionless treatment modality for ET and PD. Although these technologies have been used clinically since the 1990's, most studies have focused on GK, and efficacy, safety and time to treatment effect (latency) of GK and LINAC have not been compared.
View Article and Find Full Text PDFClin Cancer Res
January 2025
Mayo Clinic, Rochester, MN, United States.
Purpose: Two randomized clinical trials (STOMP and ORIOLE) demonstrated that stereotactic ablative radiotherapy (SABR) can prolong ADT-free survival or progression-free survival (PFS) in patients with metachronous oligometastatic prostate cancer (omCSPC) patients. While most omCSPC patients have a more modest delay in progression, a small subset achieves a durable response following SABR. We investigated the prognostic and predictive value of circulating PSMA-positive extracellular vesicles (PSMA+EV) and prostate specific antigen (PSA) in a biomarker correlative study using blood samples from three independent patient cohorts.
View Article and Find Full Text PDFEcancermedicalscience
November 2024
Cyberknife and Tomotherapy Center, Jinnah Postgraduate Medical Center (JPMC), Karachi 75510, Pakistan.
Introduction: The role of stereotactic radiosurgery (SRS) in pituitary adenomas (PAs) is evolving especially considering its safety. Existing literature is hampered by limited sample sizes and short-term follow-ups, impeding its preeminence in the clinical and radiological outcomes. We propose a comprehensive, single-centred study to evaluate the outcomes following CyberKnife stereotactic radiosurgery (CK SRS) for PAs in a larger patient population, incorporating meticulous clinical and radiological follow-up.
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