AI Article Synopsis
- The study examined the effects of various 5-HT1A and 5-HT2 agents on HPA axis activity by measuring plasma corticosterone levels.
- It found that these drugs increased corticosterone levels in a dose-dependent fashion, with specific ED50 values for each agent and peak effects occurring between 30 minutes and 1 hour.
- Additionally, in stressful conditions, gepirone and enciprazine elevated corticosterone levels while carvotroline had the opposite effect, and pretreatment with dexamethasone diminished the HPA axis activity induced by the drugs.
Article Abstract
The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT1A agents) and carvotroline (5-HT2) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED50 values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity.
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| http://dx.doi.org/10.1159/000139513 | DOI Listing |
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