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Haizao-Gancao herb pair ameliorates propylthiouracil-induced goiter by regulating the Beclin1-mediated autophagy.
J Ethnopharmacol
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:
Ethnopharmacological Relevance: Haizao, Sargassum, is widely used to treat goiter. Gancao, Glycyrrhizae radix et rhizome, is renowned for reducing toxicity or increasing effects in traditional Chinese medicine. As a classic herb pair, Haizao-Gancao (HG) is a commonly used and effective combined therapy for goiter.
View Article and Find Full Text PDFDevelopment and validation of UPLC-MS/MS method for 5-Fluorouracil quantification in dried blood spot.
Heliyon
May 2024
Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, Indonesia.
5-Fluorouracil is an antimetabolite drug indicated for cancer treatment. Therapeutic drug monitoring of 5-Fluorouracil is necessary because 5-Fluorouracil has narrow therapeutic window and its concentration in blood is affected by individual conditions, like gene polymorphisms. Dried Blood Spot (DBS) is one of the biosampling methods used for therapeutic drug monitoring.
View Article and Find Full Text PDFGinseng extracts improve circadian clock gene expression and reduce inflammation directly and indirectly through gut microbiota and PI3K signaling pathway.
NPJ Biofilms Microbiomes
March 2024
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa-dong, Ilsandong-gu, Goyang-si, 10326, Republic of Korea.
Article Synopsis
- Ginseng (Panax ginseng) is recognized for its potential health benefits, specifically in enhancing body temperature and gut health, though the exact mechanisms remain poorly understood.
- This study shows that periodic supplementation with ginseng extracts positively influences body temperature and reduces inflammation in certain metabolic organs of rats experiencing induced hypothermia, likely affecting gut hormone levels and microbiota composition.
- In laboratory tests, ginseng extracts were found to influence gene regulation related to the body’s internal clock and inflammation, potentially through direct cellular action or by interacting with gut microbiota, with involvement of PI3K-AKT signaling pathways noted as a key factor.
Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
J Ethnopharmacol
November 2023
Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:
Ethnopharmacological Relevance: Haizao Yuhu decoction (HYD) is a classic Chinese herbal formula described in the surgical monographs of the Ming Dynasty "Waikezhengzong." It has been widely used to treat goiter for approximately 500 years and found to be particularly effective. HYD contains glycyrrhiza and sargassum.
View Article and Find Full Text PDFFatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report.
J ASEAN Fed Endocr Soc
December 2022
Division of Pulmonology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, particularly infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that result in the dysfunction of various vital organs. We report a case of a 31-year-old Indonesian female with a 2-year history of hyperthyroidism with elevated thyroid-stimulating hormone (TSH) receptor antibodies. (TRAb) who developed thyroid crisis possibly in association with SARS-CoV-2 pneumonia, sepsis, and disseminated intravascular coagulation (DIC).
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