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Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages. | LitMetric
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Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.

P A Denoel R M Crawford M S Zygmunt A Tibor V E Weynants F Godfroid D L Hoover J J Letesson

Infect Immun

U. R. Biologie Moléculaire, Laboratoire de Microbiologie et d'Immunologie, Facultés Universitaires Notre Dame de la Paix, Namur, Belgium.

Published: October 1997

A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not essential for the intracellular survival of B. melitensis in human MDM.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC175622PMC
http://dx.doi.org/10.1128/iai.65.10.4337-4340.1997DOI Listing

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