AI Article Synopsis
- A survey was conducted to investigate gamma-chain allotypes in different lagomorph genera, focusing on variations in the constant region of the IgG molecules.
- Only Pronolagus rupestris, a type of lagomorph, exhibited a d12-like determinant but lacked the widespread e15 determinant commonly found in rabbits.
- A new enzymatic method was developed to identify the d12 determinant, which indicated that Pronolagus lacks a significant amount of IgG molecules with a glycosylated hinge compared to rabbits.
Article Abstract
A survey for constant region gamma-chain allotypes (de locus) was undertaken in different lagomorph genera. As yet only Pronolagus rupestris, a paleolaginae, showed the presence of a determinant similar to rabbit d12 although it lacked the widespread e15 determinant. All seven individuals possessed the d12 like determinant which was studied by immunodiffusion, haemagglutination inhibition, radiobinding and binding inhibition assays. In addition, a new enzymic method for typing for d12, based on the presence of the asymmetric rabbit hinge carbohydrate linked to the d12 characteristic threonine, is presented. This method suggests, however, that, unlike the d12 rabbit, Pronolagus does not seem to have a majority of IgG molecules with a glycosylated hinge.
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| http://dx.doi.org/10.1111/j.1744-313x.1979.tb00692.x | DOI Listing |
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